Into the Impossible With Brian Keating

The same mathematics that explains why a fridge magnet sticks to your refrigerator also explains why neural networks work when they have no right to. His group did the calculation. Nobody else had. Subscribe if you want science with evidence, not speculation.

Goldenfeld is a Professor of Physics at UC San Diego, a Fellow of the Royal Society, and a Member of the National Academy of Sciences who spent 36 years at the University of Illinois applying condensed matter physics to problems everyone else had given up on: why the genetic code is optimal, why early life evolved impossibly fast, and why AI works despite being overparameterized beyond anything classical statistics can explain.

The thread connecting all three is one idea: that what emerges from many things together is qualitatively different from the sum of its parts. That idea explains magnetism, AI, the origin of the genetic code, and why life may be inevitable wherever the laws of physics apply. He also argues that what is happening to science right now is not a disagreement about facts but a fracture in how people decide what is true, and that is a more dangerous problem.

What you’ll hear:

-Why the same phase transition that explains magnetism also explains why AI works at all

-Why Francis Crick concluded life must have come from outer space and what Goldenfeld found instead

-What horizontal gene transfer has to do with how libraries work

-Why Goldenfeld thinks Enceladus is a better bet for life than Europa

-The purpose of life, stated as a thermodynamics problem

-Why “different is more” is more useful than “more is different”

“The impact you make is the ratio of what you do divided by what everybody else does. Minimize the denominator.” — Nigel Goldenfeld

CHAPTERS

00:00 AI shouldn't work. It does.

00:56 What is a phase transition?

03:10 What the renormalization group does

08:54 Ising gave up. Wrong dimension.

13:32 Nigel almost met Ising. 40 minutes away.

26:38 AI is the best example of more is different

33:52 Bardeen won two Nobels. The transistor looked like chewing gum.

37:24 The three mysteries Crick couldn't solve

46:20 The genetic code can't evolve. And yet it did.

49:00 How early life evolved like a library

57:06 The purpose of life as a physics problem

01:00:04 Life is physics, not chemistry

01:05:56 Anti-science age. Not because of opinions.

01:13:00 20 seconds with your 20-year-old self

01:17:14 Different is more

Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt

Have a .edu email and live in the USA? You automatically win a meteorite: https://BrianKeating.com/edu

Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1

Support Into the Impossible on Patreon, get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating

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Featured Guest:

Nigel Goldenfeld website: https://guava.physics.ucsd.edu/~nigel/

Lectures on Phase Transitions and the Renormalization Group: https://www.amazon.com/dp/0201554097?lv=shuf&channelId=500&plpRedirect=mhFallbackNigel Goldenfeld on Twitter/X: https://x.com/NigelGoldenfeld

My books:

Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA

Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu

Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U

Galileo’s Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un

Twitter/X: https://x.com/BrianKeating

Substack: https://briankeating.substack.com

Blog: https://briankeating.com/blog

Audio-only: https://briankeating.com/podcast

#intotheimpossible #briankeating #NigelGoldenfeld #physics #AI #originoflife #condensedmatterphysics #podcast
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The system that produces the world’s most important discoveries runs on metrics that nobody agrees on, odds that would stop most people, and mentorship that sometimes looks like cruelty in blue ink. Subscribe if you want science with evidence, not speculation.

Lipomi is Professor and Chair of Chemical and Sustainability Engineering at the University of Rochester and the author of Science Nonfiction: Behind the Scenes in University Research. His lab works on organic electronics, materials science, recyclable polymers, and the science of human touch. He trained under George Whitesides at Harvard, one of the most cited chemists who has never won the Nobel Prize.

The conversation covers the H-index, what elite mentorship actually looks like when your advisor writes “This is illiterate” in blue ink on your outline, and what the future of academic research versus industry careers looks like in an era of AI, demographic headwinds, and graduate school debt that can’t be discharged in bankruptcy. We also get into homochirality, OLED displays, and why Lipomi thinks the nanotechnology revolution already happened, we just didn’t call it that.

What you’ll hear:

-Whether the academic system is designed to produce scientists or to filter them out

-What is Baumol’s cost disease and why it explains rising tuition costs

-Why the nanotechnology revolution already happened and nobody called it that

-How nanotechnology is used in cancer drug delivery today versus what science fiction promised

-What it actually takes to build a PhD career at the intersection of chemistry, mechanics, and neuroscience

-Whether engineering students should be reading Plato — and what countries that skip it are getting right

“Find a skill at the intersection of three or more interests that no one else is working on.” — Darren Lipomi

CHAPTERS

00:00 He says don't go to college. He runs the department.

01:10 The H-index: imperfect, irreplaceable

02:04 1 in 20 PhDs gets the job

05:42 The meteorite and the origin of life

08:34 Did life's asymmetry come from space?

12:00 Who is an organic materials chemist at 3am?

13:52 The collaboration that started at a coffee shop

15:22 The nanobot revolution already happened

18:24 Nanotechnology inside your body right now

19:08 The $70 billion invention Kodak gave away

22:12 Kodak, Xerox, Bausch + Lomb: what Rochester built

26:06 Working under Whitesides at Harvard

28:54 What he wrote on the outline in blue ink

30:38 Who you work with matters more than what you work on

31:56 Department chair: hostage negotiator, not boss

34:36 Why the department changed its name after 110 years

36:00 The headwinds have never been stronger

38:44 Should engineers read Plato?

39:38 The debt you can't discharge in bankruptcy

40:06 Do you buy Baumol's cost disease?

43:14 Why he had to write the book

48:16 The Fisher-Price camcorder experiment

51:06 Teaching in one sentence. Research in one.

53:42 Losing Darren to Rochester: the Fernando Tatis analogy

Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt

Have a .edu email and live in the USA? You automatically win a meteorite: https://BrianKeating.com/edu

Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1

Support Into the Impossible on Patreon, get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating

Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join
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John Martinis won the 2025 Nobel Prize in Physics for proving macroscopic quantum tunneling is real. Less than a year later he’s telling why he left Google’s quantum computing team to start over. Subscribe if you want the physics and the politics of building the impossible.

Martinis is the co-founder of Colab and one of the physicists who proved ordinary quantum rules apply to macroscopic systems. He built his career on the same Josephson-junction hardware his Nobel is built on, then led Google’s superconducting-qubit effort, the same team behind Google’s 2019 quantum supremacy claim, before an internal reorg pushed him out.

We go into Anthony Leggett’s challenge to Schrödinger’s cat, what decoherence in quantum mechanics really means, and whether quantum computing is the first technology ever born from pure theory rather than experiment. We also cover the internal Google reorg that pushed Martinis out and what he learned about building something new inside a large institution.

Whether quantum mechanics applies to the macroscopic world and what it took to prove it

Why Martinis thinks quantum computing may be the first technology born from pure theory, not experiment

What negative authority means and why it matters for anyone building something new inside a large institution

Whether the US can win the quantum computing race against China

How Martinis thinks about quantum mechanics interpretations after spending a career inside the math

“Always be on the lookout for the impossible, right?” John Martinis

CHAPTERS

00:00 The Nobel call that almost wasn't

01:01 How his wife found out before he did

03:32 Anthony Leggett's challenge to Schrödinger's cat

05:53 Why a Josephson junction, not a quantum dot or trapped ion

07:45 Quantized oscillations: the “smoking gun” and Balmer's ghost

08:18 Measuring the system: the resonance experiment

11:21 Systematic effects: what separates a good scientist from a lucky one

13:42 The Ed Ohm story: the man who found the CMB and doubted it

15:01 Wigner's “unreasonably effective” math and the weirdest thing about QM

16:54 The transistor myth: chewing gum, coat hangers, and germanium

17:34 Microwave engineering meets quantum mechanics

19:26 Decoherence: the friction you can't live without

24:06 The heretical claim: does theory ever precede technology?

28:22 The “paper qubit” problem

29:34 What quantum computers are actually good for

32:27 Should quantum computing be regulated like AI?

33:35 US vs. China: the quantum computing race

35:44 Collapse, Copenhagen, or many worlds? Martinis's answer

37:43 Leaving Google: “essentially demoted”

40:48 Why Colab exists and what “negative authority” means

42:50 The real bottleneck: funding, not physics

43:31 Final advice: always be on the lookout for the impossible

Qolab: https://qolab.ai/

Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt

Have a .edu email and live in the USA? You automatically win a meteorite: https://BrianKeating.com/edu

Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1

Support Into the Impossible on Patreon, get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating

Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join

My books:

Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA

Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu

Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U

Galileo's Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un

Twitter/X: https://x.com/BrianKeating

Substack: https://briankeating.substack.com

Blog: https://briankeating.com/blog

Audio-only: https://briankeating.com/podcast

Landing page: https://awake-mill-k25t.here.now

#intotheimpossible #briankeating #JohnMartinis #NobelPrize #quantumcomputing #physics #podcast
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Scott Dodelson spent ten years on the Dark Energy Survey testing the standard model of cosmology. It passed and missed by 2.5 sigma. The Director of Fermilab’s Cosmic Physics Division on why the theory he helped build may be wrong, why nobody can find dark matter, and what it takes to change a scientific consensus. Subscribe if you want science with evidence, not speculation.

Dodelson is Director of the Cosmic Physics Division at Fermilab, Professor of Astronomy and Astrophysics at the University of Chicago, and author of Modern Cosmology, the textbook a generation of cosmologists learned the field from.

Lambda-CDM predicts how the early universe’s tiny fluctuations grew into the structure we see today. The Dark Energy Survey was designed to check that prediction. The answer came back two and a half sigma off. That is both the most precise measurement ever made of how the universe grew, and a crack he cannot stop looking at. His question is not whether the model is close. It is whether close is enough to trust.

We get into the Sigma-8 tension and what it actually takes for a scientific community to change its mind, the Dodelson-Widrow mechanism and his 1994 proposal that sterile neutrinos produced in the early universe could constitute dark matter, and the Neptune vs. Vulcan history of getting dark matter right and wrong. Asked which of those two situations we are in now, Dodelson’s answer is: I have no idea.

What you’ll hear:

Why the April 24, 1992 CMB discovery may have been the only science story ever to lead the New York Times front column

The Dodelson-Widrow mechanism: how ordinary neutrinos in the early universe may have oscillated into the dark matter we see today

Why Brian told Neil deGrasse Tyson to his face that we have already detected dark matter

What it means when a theory can accommodate any result and whether inflation has that problem

Why the particle physics community still does not trust cosmology’s neutrino mass measurements

What cosmology looks like in 2036 if Lambda-CDM breaks

Killing the model is my dream.

0:00 None of it has been found in a lab. How many free passes do we get?

0:44 Dodelson helped build Lambda-CDM. His dream is to kill it.

2:10 10 years. One prediction. Two and a half sigma off.

5:42 "You're in charge" — what mentorship in science actually looks like

6:56 April 24, 1992: cosmology stopped being speculation

9:48 Geoff Burbidge went to his grave a steady-state believer

11:04 What a neutrino is and why it barely interacts with anything

12:36 Brian told Neil deGrasse Tyson we already detected dark matter

18:08 How ordinary neutrinos may have become dark matter

23:24 Lambda-CDM predicts Manhattan's density 13.7 billion years later

26:42 Two and a half sigma: technically a 1% chance the theory is right

28:04 Neptune was dark matter. Vulcan wasn't. Which one are we in now?

31:20 Dark matter, inflation, dark energy: none found in a lab

36:46 If both cracks are the same crack, Lambda-CDM is finished

Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt

Have a .edu email and live in the USA? You automatically win a meteorite: https://BrianKeating.com/edu

Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1

Support Into the Impossible on Patreon, get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating

Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode: https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join

Featured Guest:

Scott Dodelson Substack: https://scottdodelson.substack.com/about

Scott Dodelson on LinkedIn: https://www.linkedin.com/in/scott-dodelson-b6ba429/

Scott Dodelson on Twitter/X: https://x.com/ScottDodelson

Modern Cosmology (book): https://www.sciencedirect.com/book/monograph/9780128159484/modern-cosmology

Dark Energy Survey final results: https://www.darkenergysurvey.org/news-and-results/darchives/

Dodelson and Widrow 1994, Sterile neutrinos as dark matter: https://arxiv.org/abs/hep-ph/9303287

Previous ITI episode with Kyle Dawson on DESI: https://youtu.be/LPx4oiwGp2k?si=u_ZJWfJG5AhvBAEv

My books:

Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA

Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu

Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U

Galileo’s Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un

Twitter/X: https://x.com/BrianKeating

Substack: https://briankeating.substack.com

Blog: https://briankeating.com/blog

Audio-only: https://briankeating.com/podcast

#intotheimpossible #briankeating #cosmology #darkmatter #darkenergy #physics #LambdaCDM #podcast
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Two theoretical physicists helped design landmark surveys of 1,600+ scientists on the deepest unsolved questions in physics — and found almost no consensus at all.

From string theory's shockingly low support to physicists admitting their models run on "belief," this episode exposes the faith hiding inside science.

Adam Frank (University of Rochester astrophysicist and astrobiologist) and Niayesh Afshordi (Perimeter Institute / University of Waterloo cosmologist, co-author of the APS Physics Magazine "Big Mysteries" survey) join Brian to unpack what physicists actually believe versus what they can prove.

We cover:

- Why string theory pulled a shockingly small share of the vote against loop quantum gravity
- What a Bayesian "prior" reveals about every scientist's hidden beliefs
- Why one branch of physics quietly became unfalsifiable
- How sociology and "tastemakers" can hijack scientific consensus
- Why AI might become the field's unlikely savior.

There is no sane statistical analysis that doesn't have a prior — that's your belief.

Timestamps:

00:00 – Why scientists owe the public real answers
04:00 – Splitting time between research and outreach
07:55 – The survey that "rankled" Brian Keating
09:18 – Are physicists secretly just like Spock?
12:05 – Are we living in an anti-scientific age?
16:56 – Why most scientists refuse to go public
21:36 – Should "belief" ever appear in a survey?
23:12 – Is string theory really 21st-century physics?
26:20 – When sociology hijacks scientific consensus
28:39 – The hidden "prior" behind every experiment
33:01 – String theory's shockingly low vote count
39:03 – Four levels of belief, from data to faith
41:39 – Inside the 1,675-physicist mystery survey
46:12 – Kingmakers, tastemakers, and physics cliques
54:12 – Is advanced tech indistinguishable from magic?
59:23 – Could AI become physics' long-awaited savior?
1:01:47 – What's next for Adam and Niayesh

———

📬 Get the transcript, fascinating bonus content, and my Monday M.A.G.I.C. Message: https://briankeating.com/yt

🌠 Have a .edu email and live in the USA 🇺🇸? You automatically win a meteorite: https://BrianKeating.com/edu

🔔 Subscribe: https://www.youtube.com/DrBrianKeating?sub_confirmation=1

🎯 Support Into the Impossible on Patreon — get my weekly M.A.G.I.C. Message, unfiltered bonus content, and live monthly Office Hours with me: https://www.patreon.com/drbriankeating

⭐ Join this channel for perks, monthly Office Hours, and your name in the Member Roster at the end of every episode:

https://www.youtube.com/channel/UCmXH_moPhfkqCk6S3b9RWuw/join

📚 My books:

Losing the Nobel Prize (memoir): http://amzn.to/2sa5UpA
Think Like a Nobel Prize Winner: https://a.co/d/03ezQFu
Focus Like a Nobel Prize Winner: https://a.co/d/hi50U9U
Galileo's Dialogue (first-ever audiobook): https://a.co/d/iZPi9Un

🌐 More:

🏄‍♂️ Twitter: https://twitter.com/BrianKeating
📚 Substack https://briankeating.substack.com/ss
✍️ Blog: https://briankeating.com/blog
🎙️ Audio-only: https://briankeating.com/podcast

#intotheimpossible #briankeating #science #physics #astronomy #cosmology #podcast #universe

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