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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • The Strange Science Behind Tylenol and Heartbreak | Daniel Amen : 1358
    Pain isn’t just in your body, it’s in your brain. In this groundbreaking episode, Host Dave Asprey sits down with Dr. Daniel Amen to reveal how emotional and physical pain share the same neural circuits and how you can rewire them for relief, resilience, and longevity. You’ll learn practical tools to break the “doom loop” of pain, restore neuroplasticity, and retrain your brain for calm, healing, and high performance. This is essentiallistening for anyone ready to stop managing pain and start hacking it. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR The Washington Post called Dr. Daniel Amen the most popular psychiatrist in America. He is a former infantry medic and board certified child and adult psychiatrist who trained at the Walter Reed Army Medical Center in Washington, DC. He is the CEO and founder of Amen Clinics, with 11 locations nationwide and home to the world’s largest brain imaging database for psychiatry with nearly 300,000 SPECT scans on patients from 155 countries. Dr. Amen is a 12 time New York Times bestselling author, including the books Change Your Brain, Change Your Life, Healing ADD, Memory Rescue, Raising Mentally Strong Kids, and The End of Mental Illness. He has published over 90 scientific articles and led groundbreaking brain imaging research on NFL players, childhood trauma, negativity bias, reversing brain aging, obesity and the brain, and predicting treatment responses. With over 10 million followers and multiple PBS specials, his mission is bold: to end mental illness by creating a revolution in brain health. His newest book Change Your Brain, Change Your Pain explores the neuroscience of pain and how to heal it through brain optimization and functional medicine. Host Dave Asprey and Dr. Amen uncover how suppressed emotions, inflammation, gut health, and mitochondrial function all influence pain and what you can do to reverse it using biohacking, functional medicine, and supplements. They explore how chronic pain rewires neural pathways, how to activate your brain’s natural calming switch, and why techniques like hypnosis, red light therapy, rage journaling, and havening can restore balance to your nervous system. You’ll also learn the surprising links between aspartame, Tylenol, and generational anxiety, and how to protect your mitochondria to optimize energy, metabolism, and emotional resilience. This episode delivers practical, science based tools for brain optimization, sleep optimization, neuroplasticity, and anti aging while connecting the dots between biohacking, psychology, and functional medicine to help you live smarter not harder. You’ll Learn: • How emotional pain and physical pain run on the same brain circuits • Why suppressed rage can trigger chronic pain and how to release it • The link between inflammation, gut health, and brain suffering pathways • How supplements like saffron, curcumin, and omega 3s support pain relief and mood • Why red light therapy, hypnosis, and havening boost neuroplasticity and calm the nervous system • How environmental toxins, aspartame, and Tylenol disrupt mitochondria and increase pain • Simple daily habits to retrain your brain for resilience, optimism, and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: chronic pain neuroscience, emotional pain circuits, Change Your Brain Change Your Pain, Dr. Daniel Amen, Dave Asprey, biohacking, neuroinflammation, anterior cingulate cortex, SPECT imaging, mitochondrial metabolism, functional psychiatry, neuroplasticity, rage therapy, havening technique, red light therapy, saffron supplements, aspartame toxicity, gut brain axis, trauma healing, pain hacking BrainMD Happy Saffron Plus: Order Your Saffron Plus Here: https://www.awin1.com/cread.php?awinmid=89351&awinaffid=855302&ued=https%3A%2F%2Fbrainmd.co…Use Dave’s 15% OFF Discount Code: DAVE15Please note – works on one-time purchases or the first order of a subscription.Thank you to our sponsors! • NeuroVeda Health | Go to https://www.neurovedahealth.com/asprey to learn more and book your week. • AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. • BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. • ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Dave's Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated• Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 — Trailer 01:25 — Dr. Amen’s Brain Scan Research 02:11 — Physical vs Emotional Pain 05:15 — Childhood Trauma and Pain 08:10 — The Doom Loop Explained 14:01 — Havening Technique 18:27 — Training Positivity and Hope 22:11 — Rage Therapy and Journaling 26:44 — COVID and Brain Inflammation 29:41 — Mitochondria and Energy 36:14 — Pain Relief Protocol 39:32 — Saffron for Pain 43:28 — Aspartame and Anxiety 47:30 — Pain Switches in the Brain 50:50 — Red Light Therapy 52:39 — Fear and Pain Loops 56:36 — Environmental Toxins58:21 — Final ThoughtsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • The New SCIENCE of Energy Healing | Biohacking Updated : 1357
    Your body does not just run on food or supplements. It runs on energy and information. This episode reveals how to harness that energy for faster recovery, stronger mitochondria, and better emotional resilience. You will learn how energy fields, frequency, and information medicine are reshaping the science of human performance, longevity, and anti-aging. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Harry Massey, a British entrepreneur, filmmaker, and visionary in the field of bioenergetics. In his 20s, Harry’s health collapsed after a series of physical injuries, viral infections, and emotional trauma left him bedridden for seven years with chronic fatigue syndrome. Conventional medicine could not provide answers, so Harry began studying energy and information as the missing foundations of human health. His discovery of the pioneering research of Australian scientist Peter Fraser led to a breakthrough. Using Fraser’s early frequency-imprinted remedies, Harry experienced a dramatic recovery and went on to co-found NES Health, now Energy4Life, to bring this new field of bioenergetics to the world. Backed by published studies at UC San Diego showing a 22 percent increase in mitochondrial efficiency and the activation of more than 1,000 genes for cell resilience, Harry’s work unites ancient healing wisdom with modern physics, light therapy, and quantum biology. Together, Dave and Harry explore how bioenergetics, light frequencies, and digital information enhance neuroplasticity, metabolism, and sleep optimization more effectively than supplements or nootropics alone. You will discover how trauma drains energy, how to restore it through the body’s natural field communication systems, and how wearable tech and AI are transforming functional medicine. You’ll Learn: • How bioenergetic wearables increase mitochondrial energy by 22 percent • Why emotional trauma and energy leaks accelerate aging • How structured water and light frequencies store biological information • The connection between quantum biology, neuroplasticity, and healing • How energy fields regulate longevity, metabolism, and brain optimization • Why AI-powered diagnostics and frequency medicine are the next frontier in biohacking Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: energy healing, bioenergetics, Harry Massey, Dave Asprey, Energy4Life, NES Health, Infoceuticals, GEM wearable, frequency medicine, energy field, quantum biology, mitochondria, neuroplasticity, functional medicine, human performance, longevity, sleep optimization, anti-aging, metabolism, trauma healing, brain optimization, light therapy, structured water, information medicine, UCSD study, Peter Fraser, energy medicine, energy hacking, biohacking, nootropics, supplements, ketosis, fasting, AI, smarter not harder, Danger Coffee **Grab a generous discount from Harry at https://e4l.com/dave **Thank you to our sponsors! -BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order. -AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15• Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Trailer 1:25 – Seven Years Bedridden 3:50 – Three Traumatic Events at 21 6:43 – Searching for Answers 9:02 – Meeting Peter Fraser in LA 11:10 – Dave’s Skepticism About Homeopathy 17:42 – The GEM Wearable Device 20:29 – Mitochondrial Efficiency Research 27:05 – Body as Signaling Networks 30:49 – Challenging the Chemical Model 35:10 – Biohacking and Ancient Practices 36:15 – Future of Bioenergetics 44:40 – Closing Thoughts on Energy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Your Body Has an Anti-Aging Switch (Here’s How to Turn It On) : 1356
    What if getting older had less to do with your birthday and more to do with the health of your cells? Some people in their 50s feel stronger and sharper than ever, while others feel decades older than they are. The difference isn’t luck or expensive treatments. In this video, you’ll learn what really drives aging, how to measure it, and the surprising practices that can help you feel younger, stronger, and more focused right now.Chapters0:00 – Introduction0:21 – Why aging isn’t about time0:49 – Biological age vs chronological age1:40 – Cellular dysfunction and mitochondria3:00 – How weak mitochondria accelerate aging4:00 – Turning on your body’s switch6:44 – REHIT workouts to build new mitochondria8:45 – Fueling with fats for clean energy10:05 – Your body’s deep clean process13:56 – Fasting methods that support renewal15:58 – The hidden factor: chronic stress19:02 – Stress hacks to unlock longevityConnect with Dave Asprey!Thank you to our sponsor!-MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • What Happens When You Live Inside a Quantum Field? (Anti-Aging Secrets) : 1355
    Discover how quantum energy, frequency medicine, and consciousness science are rewriting what’s possible for human performance and longevity. This episode reveals how your biofield, mitochondria, and brain can be trained, just like your muscles, to achieve higher focus, deeper resilience, and accelerated healing. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Philipp Samor von Holtzendorff-Fehling, founder and CEO of Leela Quantum Tech, about the cutting-edge research proving that quantum energy can neutralize EMF damage, improve neuroplasticity, and activate self-healing at the cellular level. A former telecom executive turned energy researcher, Philipp has led dozens of double-blind, placebo-controlled studies validating measurable shifts in brain waves, ATP production, blood flow, and human coherence. You’ll learn how quantum energy interacts with your nervous system, mitochondria, and electromagnetic environment to unlock higher states of consciousness and energy. Philipp and Dave dive into the science behind biofield technology, the real dangers of 5G and EMFs, and how to use frequency devices, structured water, and energetic optimization to enhance your metabolism, sleep quality, and emotional stability. You’ll Learn: • How quantum energy measurably enhances brain coherence, ATP production, and longevity • Why EMFs disrupt your mitochondria, and the proven ways to neutralize their effects • How frequency medicine and structured water improve resilience and energy levels • What double-blind studies reveal about human performance, neuroplasticity, and healing • How to integrate quantum tech with fasting, nootropics, and supplements for full-body optimization • The role of consciousness and energy fields in unlocking true anti-aging and human potential This conversation bridges biohacking and functional medicine, exploring how quantum biology complements nootropics, fasting, ketosis, and supplements to accelerate anti-aging and brain optimization. You’ll walk away with a new understanding of energy as the missing link in hacking your biology and extending your longevity. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: quantum energy, Leela Quantum Tech, Philipp Samor von Holtzendorff-Fehling, biohacking, EMF protection, frequency medicine, human performance, mitochondria, neuroplasticity, ATP production, brain optimization, anti-aging, functional medicine, structured water, consciousness, energy healing, nootropics, sleep optimization, longevity, quantum biology **Go to https://leelaq.com/dave for a discount on Leela Quantum!**Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Intro 7:04 — Why Quantum is Controversial 10:11 — How Quantum Healing Works 14:47 — EMF Effects on the Brain 17:35 — Living in the EMF Soup 20:55 — Elon Musk and EMF Denial 22:32 — How Leela Quantum Technology Works 26:29 — Water Optimization Research 34:54 — Charging Clothing and Objects 37:31 — Frequency Medicine Applications 42:03 — Skeptics Turned Believers 55:40 — The Energy of Everything (Book Launch) 59:05 — Quantum Upgrade Service Settings 1:02:21 — Protection from Negative Energy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Master Stress in 10 Seconds with THIS Heartbeat Technique : 1354
    Heart rate variability isn’t just a fitness metric, it’s the master signal of human performance, emotional regulation, and longevity. This episode reveals how you can use HRV to hack your nervous system, regulate stress in real time, and build true resilience from the inside out. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Rollin McCraty, Ph.D., Director of Research at the HeartMath Institute and a leading psychophysiologist exploring how the heart, brain and human consciousness are interconnected. For more than three decades his pioneering research into heart-brain communication and geomagnetic field interactions has supported the development of HRV/coherence-training tools and coherence biofeedback technology. His work has been featured in documentaries such as I Am, The Power of the Heart and The Living Matrix. Together, Dave and Dr. McCraty uncover how heart-brain coherence can improve neuroplasticity, optimize sleep, strengthen mitochondria, and create emotional stability even under extreme stress. You’ll discover how five minutes a day of coherence training can elevate focus, resilience, and connection, helping every other biohack, from fasting and ketosis to supplements and nootropics, work more effectively. You’ll Learn: • What HRV really measures and why it predicts performance and longevity • How coherence breathing balances your nervous system and sharpens cognition • Why emotional regulation begins in the heart, not the mind • How environmental and solar energy affect your physiology, and how to stay stable • The Navy-proven HRV method for better sleep and stress recovery • How coherence training outperforms traditional meditation for daily resilience • The measurable science behind “radiating love” and creating heart-based connection This is essential listening for anyone serious about biohacking, brain optimization, functional medicine, and anti-aging. Whether you’re optimizing metabolism, fine-tuning sleep, or upgrading your energy with Danger Coffee, coherence training helps you live smarter, not harder, by syncing your biology with the rhythm of life itself. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: heart rate variability, HRV training, HeartMath, Rollin McCraty, heart-brain coherence, biohacking, emotional regulation, nervous system, stress resilience, neuroplasticity, longevity, sleep optimization, mitochondria, functional medicine, anti-aging, coherence breathing, vagus nerve, HRV recovery, brain optimization Go to the following link for 15% off the HeartMath device:https://store.heartmath.com/innerbalance?utm_source=2163&utm_medium=affiliate&cpclid=f6b91c4679184c83b42560e381159591&utm_campaign=The+Dave+Asprey+Group Thank you to our sponsors! -Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. -BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • HeartMath Instagram: https://www.instagram.com/heartmath/ • HeartMath Facebook: https://www.facebook.com/HeartMath • HeartMath TikTok: https://www.tiktok.com/@heartmathinc • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — OG Biohacker 3:21 — What Is Heart Rate Variability? 7:10 — The Four Drummers: Understanding HRV Rhythms 11:50 — Real-Time Training vs Sleep Tracking 18:45 — The Science of Coherence and Consciousness 21:25 — Heart Synchronization in Groups 26:40 — Space Weather and Planetary Rhythms 31:40 — Solar Flares and Human Behavior 38:45 — The Emotional System Runs the Show 49:15 — Getting Started: Training Protocol 57:55 — Advanced Applications: Dating to Performance 1:01:46 — The Frequency Spectrum of Love 1:05:15 — The Heart’s Magnetic Field and Congruence See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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About The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
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