The Human Upgrade: Biohacking for Longevity & Performance

Most women are suffering for years from anxiety, gut problems, low libido, and brain fog because no one is treating the real cause: their hormones. This episode is a masterclass in women's hormone optimization, covering everything from vaginal delivery of bioidentical hormones to why low estrogen destroys your gut, your sex drive, your mitochondria, and your marriage.

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Dr. Sarah Daccarett, MD, a physician, longevity expert, and the founder and CEO of Inner Balance, a modern women's health company redefining hormone therapy, sexual wellness, and aging. She has treated tens of thousands of women across all 50 states and is known for challenging outdated medical models and building science-driven solutions that reflect female biology rather than borrowing protocols designed for men. She created Oestra, a revolutionary hormone therapy delivery system, along with Libida, an on-demand libido solution that targets desire at the brain level, making her one of the most credible and innovative voices in functional medicine and women's longevity today.

Together, they expose why conventional medicine has failed women for decades, why patches and pills are nearly useless, and what actually works for anti-aging, metabolism, longevity, and human performance. Dr. Sarah makes the case that hormone replacement therapy is not a last resort for menopausal women. It is a foundational longevity strategy that every woman should consider starting in her 20s.

You'll Learn:
Why vaginal hormone delivery outperforms every other delivery method for women
How low estrogen destroys your gut lining, gallbladder, and immune system long before menopause symptoms appear
Why a carnivore or animal-based diet raises estrogen and why fiber lowers it
How progesterone converts to testosterone in women, and why you may not need a testosterone prescription
The real reason SSRIs get prescribed when hormone replacement therapy should come first
Why iodine is essential for breast health, estrogen metabolism, and thyroid function
How oxalates from "superfoods" like matcha, spinach, and almonds accumulate in your ovaries, uterus, and kidneys
Why both partners need hormone replacement therapy for a relationship to thrive
How hormones control mitochondria, dopamine, norepinephrine, and every system in your body

Thank you to our sponsors!
- Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off.
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Dr. Sarah Daccarett, Inner Balance, women's hormone therapy, bioidentical hormones, vaginal hormone delivery, estrogen deficiency, progesterone therapy, hormone replacement therapy, perimenopause, testosterone women, COMT genetics, FSH hormone, iodine deficiency, oxalates health, leaky gut hormones, women's longevity, biohacking, Dave Asprey, human performance, functional medicine, anti-aging

Resources:
• Visit Sarah’s Website and use code ‘PODCASTDRSARAH’: https://www.innerbalance.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
0:00 – Trailer
1:15 – Introduction
2:43 – The Gender Gap in Hormone Care
5:14 – Why Women's Hormone Therapy Is Stuck in the 1960s
8:09 – Why Young Women Are Losing Their Hormones
9:33 – Toxins, Birth Control & Hormone Disruption
14:07 – How Fiber Steals Your Hormones
19:53 – Hormones, Libido & Brain Chemistry
32:13 – Pills, Patches & Why They Fail
36:54 – Why Vaginal Delivery Works Best
44:36 – Symptoms of Low Hormones
46:07 – Leaky Gut Is a Hormone Problem
47:38 – How Low Hormones Destroy Relationships
52:28 – Thyroid, Iodine & Sex Hormones
1:00:29 – Progesterone for Men
1:05:18 – Oxalates, Kidney Stones & Your Diet
1:11:13 – Where to Find Dr. Sarah
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Frog venom burns your skin, makes you purge, and might be the most powerful healing tool you have never tried. In this episode, Host Dave Asprey sits down with Kambo researcher and practitioner Caitlin Thompson to break down how intentional suffering through this ancient Amazonian medicine is producing dramatic results for people with autoimmune conditions, chronic illness, Lyme disease, addiction, and metabolic dysfunction. From the peptide science behind the purge to the biohacking case for voluntary pain, this conversation will change how you think about healing, resilience, and human performance.

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Caitlin Thompson is an internationally recognized Kambo practitioner and educator who has guided over 2,700 clients through this medicine, with a focus on Lyme disease, autoimmune conditions, and chronic illness. Her path into this work was shaped by her own recovery from Lyme disease and Lupus. Trained in neurobiology and rooted in psychedelic science, immune health, and the human microbiome, Caitlin is currently pioneering some of the first prospective human studies on Kambo. She collaborates directly with indigenous Amazonian communities including the Matsés, Shuar, Quechua, and Matis, and has appeared on over 100 podcasts and conferences as a leading voice at the intersection of traditional medicine and modern science.

Dave and Caitlin break down the full Kambo experience, from the transdermal burns and peptide families flooding your lymphatic system, to the purge, the frog face, and the window of clarity that follows. They explore why the suffering is not a side effect but the actual mechanism, how ordeal medicine builds the same neuroplasticity and dopamine receptor sensitivity that meditation, breathwork, and ice baths produce, and why this ancient practice is becoming one of the most talked about tools in functional medicine and longevity circles.

They also dig into the sustainability crisis threatening frog populations in the Amazon, the almost nonexistent research landscape for Kambo, why journals refuse to publish positive findings, and how AI may unlock the ability to synthesize Kambo peptides and remove the dependency on frogs entirely.

You'll Learn:
Why intentional suffering through Kambo may be one of the most effective biohacking tools for immune reset and brain optimization
How Kambo peptides interact with your mitochondria, vagal nerve, and immune system to drive deep healing
Why the purge is not a side effect but a keystone mechanism of the medicine
How ordeal medicine builds dopamine receptor sensitivity and neuroplasticity similar to fasting, cold exposure, and breathwork
What the actual risks of Kambo are and how hyponatremia kills people who do it wrong
Why Caitlin recovered from Lupus and Lyme disease using Kambo and what that means for autoimmune conditions
How Kambo compares to ketamine, ayahuasca, and other altered states for trauma and performance
Why journals refuse to publish Kambo research and what that reveals about the drug development pipeline
How AI and synthetic biology may soon make frog harvesting unnecessary
What the worst Kambo practitioners do wrong and how to find someone you can actually trust

Thank you to our sponsors!
-BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com
-KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off
-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.
-Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Caitlin Thompson, Kambo practitioner, frog venom healing, Kambo ceremony, Kambo peptides, phyllo medusa bicolor, transdermal burns, hyponatremia Kambo, Kambo autoimmune, Lyme disease Kambo, Lupus recovery, ordeal medicine, intentional suffering dopamine, Kambo research, Kambo safety, Kambo training, Amazon frog medicine, Kambo vs ayahuasca, biohacking, Dave Asprey, human performance, neuroplasticity

Resources:
• Visit Caitlins Website to Learn More: https://kamboinstitute.org/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
01:15 – Introduction
05:33 – Guest Introduction
09:46 – Caitlin's Origin Story
12:46 – Kambo & Healing
16:29 – Trauma, PTSD & Psychosomatics
19:36 – What Is Kambo?
22:41 – Journey Duration
24:26 – Pharmacology & Peptides
28:55 – Publishing Challenges & Bias
30:45 – How to Do It Wrong
32:22 – Legal Status
35:14 – Synthesizing Kambo
39:34 – Indigenous Origins & Folklore
42:46 – Safety & Risks
48:56 – Where to Find Caitlin
51:25 – Pain, Resilience & BICEP
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I spent over $2 million hacking my own biology to reverse my age, but one of the most powerful discoveries didn’t come from a pharmaceutical lab. It came from NASA.

Try Danger Coffee: https://dangercoffee.com/dave (Discount Code DAVETUBE)
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Astronauts face the harshest environment known to science: space radiation. To keep them alive, NASA had to identify a nutrient dense enough to protect DNA and mitochondria from extreme oxidative stress. They found it in algae (spirulina and chlorella)—a superfood older than civilization that acts as "biological armor" for your cells.

In this episode, I break down why "aging" is actually just a buildup of oxidative stress (cellular rust) and how most antioxidants fail to fix it because they never reach the mitochondria. I reveal the exact science behind why algae works, the specific molecules (phycocyanin and chlorophyll) that protect your cellular walls, and the protocol I use to keep my liver young and my energy stable.

We also cover the critical lifestyle factors—from sleep to seed oils—that are throwing gasoline on the fire, and how to "clear the battlefield" so this superfood can actually do its job

Timestamps:
00:00 – Intro
01:03 – The Aging Myth
01:43 – How Aging Actually Starts
03:33 – Restoring Your Antioxidant Defense
04:56 – Why Most Supplements Fail
07:30 – NASA's Superfood Discovery
11:47 – How to Use Algae
13:24 – Lifestyle Factors That Undermine Algae
15:57 – Action Plan

Thank you to our sponsors!
Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off.
The One Device | Use code DAVE for $10 off at theonedevice.com/dave.

Connect with Dave Asprey!

Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your home could be quietly stealing your IQ, disrupting your hormones, destroying your mitochondria, and triggering chronic disease, and most people never connect the dots. This episode gives you the full picture on toxic mold, and exactly what to do about it

Learn More About The Superstratum Products Dave Uses At: https://superstratumlabs.com/products/dave

Host Dave Asprey sits down with Seth Jones, CEO of Superstratum and the creator of the first patent-pending process to remove mycotoxins from homes. Before founding Superstratum, Seth spent 15 years as an international songwriter, producer, and DJ until a personal experience with Building-Related Illness changed the entire direction of his life. Today he and his team are on a mission to heal the estimated 66 million homes in the U.S. that create toxic conditions for the 170 million people living inside them. If toxic mold has derailed your health, your relationships, or your ability to think clearly, this conversation will change how you see your home forever.

Dave Asprey built his entire biohacking and longevity career trying to fix what mold did to his body. By his mid-twenties, he carried diagnoses of arthritis, chronic fatigue, fibromyalgia, and mold-induced brain damage that wiped out his prefrontal cortex activity. Functional medicine doctors couldn't help him. Specialists gave up. It took him years of self-directed research into mitochondria, metabolism, and environmental toxicology to understand that his home was the root cause. He lost 100 pounds, reversed brain damage confirmed by imaging, and recovered IQ points he thought were gone for good.

In this episode, Dave and Seth break down the real science of how mycotoxins poison mitochondria, hijack hormones, crush sleep optimization, and block the neuroplasticity your brain needs to perform. They reveal why mold is additive with every other toxin in your environment, why most remediation fails, and how a systematic home detox protocol can do what no supplement, nootropic, or fasting protocol can fix on its own.

You'll Learn:
Why mold toxins are direct mitochondrial poisons and what that means for your energy, willpower, and metabolism
How mycotoxins lower your IQ by up to 15 points and why removing them reverses the damage
The estrogen-mimicking mold toxin 10,000 times stronger than human estrogen that causes weight gain no diet can fix
Why your AC and HVAC system are the most dangerous mold delivery systems in your home
How mold disables detox pathways and makes every other environmental toxin worse
The connection between toxic mold, Lyme disease, Alzheimer's, cancer, and fertility loss
Why Danger Coffee and mold-free nutrition matter as much as fixing your home
The step-by-step Superstratum protocol for fogging, bombing, coating, and restoring a healthy home microbiome
How to salvage your belongings, treat your car, and avoid recontaminating a clean environment

Thank you to our sponsors!
- Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
- Superstratum Labs | Get Dave's exact home mold detox kit and save 10% at superstratumlabs.com/products/dave

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Seth Jones, Superstratum, toxic mold symptoms, mycotoxins in homes, Building-Related Illness, mold and IQ, mold brain damage, HVAC mold, home detox protocol, hypochlorous acid mold, environmental probiotics, HomeBiotic, mold and mitochondria, mold and hormones, zearalenone estrogen, mold weight gain, mold and fertility, mold and Alzheimer's, mold and Lyme disease, ochratoxin, mold and chronic fatigue, Dave Asprey, biohacking, longevity, functional medicine, human performance, anti-aging, Danger Coffee, mold detox, brain optimization, sleep optimization

Resources:
• Learn More About The Superstratum Products Dave Uses At: https://superstratumlabs.com/products/dave
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:46 – Intro
01:27 – Dave's Mold Origin Story
02:37 – Health Decline & Recovery
06:02 – Coffee, Bulletproof & Moldy Movie
10:17 – Systemic Effects of Mold
13:24 – Introducing SuperStratum
18:04 – Weight, Hormones & Brain Damage
19:53 – Brain Scans, Sleep & Symptoms
26:09 – Fertility, Prevention & Costs
31:03 – Treating the Home
42:42 – Seth's Story
48:45 – Resources & Car Detox
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Autism is reversible, and the science to prove it already exists. This episode delivers a master class on the biological roots of autism, what actually triggers it, and the protocols that have helped real families recover their children, including one mom who sold everything she owned to make it happen.

Host Dave Asprey sits down with Tracy Slepcevic, bestselling author of Warrior Mom: A Mother's Journey in Healing Her Son with Autism, certified integrative health practitioner, Air Force veteran, and founder of Autism Health, a 501(c)(3) nonprofit organization dedicated to accelerating biomedical solutions for autism. Tracy has spent over 17 years researching treatments and therapies for autism and other neurological disorders, trained in complementary and alternative medicine, and built the Autism Health Summit into one of the most important annual gatherings for parents, physicians, and researchers in the autism recovery space. She is not a researcher observing from a distance. She is a mother who sold everything she owned, bartered for treatments, and traveled to Ukraine for stem cell therapy to recover her son Noah, who today lives a fully independent life, works full time, and travels the world alone.

Together, Dave and Tracy tear apart the myth that autism is a fixed genetic condition and expose it for what it actually is: a biological cascade triggered by a recipe of environmental factors colliding with genetic susceptibility. They cover how mitochondrial dysfunction and chronic neuroinflammation combine to create the sensory overload and cognitive fog that defines autism, why healing the gut first is the non-negotiable foundation that determines whether every other treatment works, how glyphosate, toxic mold, heavy metals, volatile organic compounds, and vaccine injury each contribute to a compounding toxic load that crosses the threshold into autism, why plasmalogen supplements are producing results in non-speaking children that the medical establishment insists are impossible, and how AI is now accelerating the ability of parents and practitioners to identify personalized biological pathways and act on them in hours instead of months. Dave also shares his own journey reversing Asperger's syndrome over ten years through biology, mitochondrial repair, neuroplasticity retraining, and supplements, and explains why catching these conditions early and acting on them aggressively with functional medicine is the difference between a life of suffering and a life of superpowers.

You'll Learn:
Why autism is biological, not purely genetic, and what environmental triggers pull the trigger on susceptible children
How mitochondrial collapse creates the energy deficit that drives sensory overload, social withdrawal, and cognitive dysfunction in autism
Why healing the gut first determines whether every other autism treatment works or fails
What plasmalogen supplements are doing for non-speaking children and adults with neurological disorders
How glyphosate, toxic mold, heavy metals, and volatile organic compounds compound into the recipe that causes autism
Why AI is transforming the ability of autism parents to identify personalized amino acid and supplement protocols overnight
How Dave reversed Asperger's syndrome through mitochondrial repair, neuroplasticity retraining, and targeted supplements
What stem cell therapy accomplished for Tracy's son Noah within 30 days of treatment
Why genetic testing before any vaccine or medication schedule should be mandatory for every child
How to clean your home environment of the VOCs, mold, and bacterial toxins that drive neuroinflammation in the whole family
Why the gifts that come with an autism diagnosis can become genuine superpowers once the biology gets fixed

Thank you to our sponsors!
- BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.
- AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.
- Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18.
- Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Tracy Slepcevic, Warrior Mom book, autism recovery, biomedical intervention autism, autism gut health, mitochondrial dysfunction autism, plasmalogen supplements, stem cell therapy autism, glyphosate autism, toxic mold neuroinflammation, vaccine injury autism, Autism Health Summit, heavy metals autism, neuroplasticity, biohacking, Dave Asprey, functional medicine, anti-aging, human performance, brain optimization

Resources:
• Visit Tracy’s Website To Learn More: www.AutismHealth.com
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
0:00 – Trailer
1:15 – Dave's Personal Autism Journey
4:26 – What Causes Autism
8:20 – Gut Health as the Foundation
10:14 – Tylenol, Vaccines & Toxic Exposures
12:21 – The Gifts & Superpowers of Autism
15:42 – AI, Peptides & Plasmalogen
22:06 – Mold, Lyme & Toxic Load
27:57 – Top Autism Contributors
31:04 – Cleaning Up Your Environment
33:35 – Glial Cells & Neuroinflammation
39:27 – Tracy's Story & Noah's Diagnosis
51:55 – Warrior Mom: Sacrifice & Recovery
54:08 – Vaccines & the Coverup
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.