MCAT Basics (from MedSchoolCoach)

• The Respiratory System

  In this episode, we cover the respiratory system, an important topic for the MCAT Bio/Biochem section. We'll go over the anatomy of the respiratory system, highlighting key structures such as the lungs, bronchi, bronchioles, and alveoli, and explain how they contribute to respiratory functions. You'll also learn about the main roles of the respiratory system, including gas exchange, thermoregulation, particle filtration, and maintaining blood pH. We’ll break down the mechanics of breathing, including the role of the diaphragm and intercostal muscles, and how pressure changes drive air into and out of the lungs. We also cover the importance of pulmonary surfactant in preventing alveolar collapse and how partial pressures influence gas movement. Visit MedSchoolCoach.com for more help with the MCAT. Jump into the conversation: (00:00) Intro (01:02) Overview: Functions of the respiratory system (01:28) Main Functions: Gas exchange, thermal regulation, particle filtration, pH control (02:20) Upper Respiratory Tract: Nose, nasal cavity, sinuses, larynx, trachea (05:00) Lower Respiratory Tract: Lungs, bronchi, bronchioles, and alveoli (09:28) Airflow Pathway: How air travels through the respiratory system (10:23) Gas Exchange: Oxygenation and CO2 removal (11:27) Breathing Mechanics: Diaphragm and intercostal muscles (13:04) Pressure Differentials: How pressure changes drive airflow (15:01) Surface Tension in Alveoli: Importance of pulmonary surfactant (18:17) Lung Compliance and Elasticity: How lung tissue stretches and returns to shape (21:48) Gas Exchange Process: Partial pressures of oxygen and carbon dioxide (24:59) Partial Pressure Explained: Role in moving gases during respiration (30:31) Thermoregulation: Maintaining body temperature through respiration (35:59) Particle Filtration: Nasal hairs and mucous cilia system (39:44) pH Regulation: How breathing controls blood pH (41:18) Respiratory Control: Involuntary and voluntary mechanisms, brainstem functions

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  44:42
• DNA Mutations and Repair

  In this episode, we focus on DNA mutations and repair, a key topic for the Bio/Biochem section of the MCAT. We'll cover the different types of mutations, including point mutations, insertions, and deletions, and explain how they occur due to replication errors or environmental factors like UV radiation. You'll also learn about the repair mechanisms that fix these genetic changes, such as direct reversal, mismatch repair, and base excision repair. We’ll also discuss how double-strand breaks are addressed through homologous recombination and non-homologous end joining. By the end of this episode, you'll gain a thorough understanding of how mutations happen and the processes the body uses to repair them, helping you prepare for related MCAT questions. Visit MedSchoolCoach.com for more help with the MCAT. Jump into the conversation: (00:00) Intro (01:07) Overview of DNA Mutations and Repair (01:45) What is a Mutation? (02:30) Mutations During DNA Replication (03:29) DNA Polymerase Slippage: Causes duplication of repeated sequences in DNA (06:15) Mutations Before or After Replication: Caused by mutagens like radiation or chemicals (07:19) Mutagens vs. Carcinogens: Differences between agents that cause mutations and those that cause cancer (09:56) Types of Mutations: Overview of point mutations, insertions, and deletions (12:00) Frameshift Mutations: How insertions or deletions shift the reading frame (29:50) Chromosomal Mutations: Inversions and translocations (35:35) DNA Repair Mechanisms: Introduction to replication repair, mutation repair, and break repair (36:51) Proofreading by DNA Polymerase: Repairing replication errors (39:20) Direct Reversal DNA Repair: Enzymes directly fix damaged DNA (40:41) Mismatch Repair: Fixing base mismatches and insertion-deletion loops (43:25) Base Excision Repair: Correcting single-base mutations (46:03) Nucleotide Excision Repair: Fixing bulky DNA damage like pyrimidine dimers (47:56) Interstrand Cross-Link Repair: Repairing DNA strands covalently cross-linked together (50:27) Single-Strand Break Repair: Ligating broken DNA strands back together (51:16) Double-Strand Break Repair: Homologous recombination and non-homologous end joining (54:13) Summary of DNA repair mechanisms

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  52:50
• Social Institutions

  In this episode, we focus on the structure and role of key social institutions for the MCAT Psych/Soc section. We'll break down the five major institutions—health and medicine, education, family, religion, and government—and explain how each shapes societal norms and individual behavior. You’ll learn about concepts like medicalization, the sick role, and how healthcare is delivered, as well as the hidden curriculum and educational segregation. We’ll also cover family structures, kinship types, and how religion influences social change. Lastly, we’ll touch on political systems and the difference between power and authority, all of which are important for the MCAT. By the end, you’ll be equipped to understand how these institutions impact society and approach related MCAT questions with confidence. Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: (00:00) Intro (01:03) Introduction to Social Institutions (01:54) Definition of Social Institutions (04:24) Formal vs. Informal Institutions (05:03) Health and Medicine: Structure and Function (07:49) Medicalization and the Sick Role (09:56) Delivery of Healthcare (12:18) Illness Experience (13:59) Social Epidemiology (17:05) Education: Structure and Function (19:37) Educational Segregation and Stratification (24:03) Teacher Expectancy (25:06) Family: Structure and Function (28:46) Violence in the Family (29:26) Religion: Structure and Function (32:25) Religion and Social Change (35:43) Government and Economy: Structure and Function (37:11) Power vs. Authority (38:23) Types of Political Systems (41:06) Division of Labor  

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  42:24
• Aromatic Compounds

  In this episode, we break down aromatic compounds, a crucial topic for the Biochem and Chem/Phys sections of the MCAT. You’ll learn what makes a compound aromatic, how to identify them using Huckel’s Rule, and the difference between aromatic, antiaromatic, and nonaromatic compounds. Sam Smith covers key examples like benzene, toluene, and phenol, and explains their role in biological systems like DNA and the electron transport chain. With practical tips and MCAT-focused insights, you'll be ready to tackle questions on aromatic compounds with confidence. Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: (00:00) Introduction and Med School Coach Promotion (01:03) Introduction to the Topic: Aromatic Compounds (02:08) Definition of Aromatic Compounds and Electron Delocalization (04:43) Explanation of Huckel’s Rule and Aromaticity Criteria (07:59) Introduction to Antiaromatic Compounds (09:58) Definition of Polycyclic and Heterocyclic Aromatic Compounds (12:02) Common Aromatic Compounds to Know: Benzene, Toluene, Phenol, Aniline (14:54) Properties of Aromatic Compounds: Physical, Stability, Fluorescence, Basicity (20:15) Aromatic Compounds in Biology: Amino Acids, DNA/RNA, Electron Transport Chain (28:14) Conclusion and Outro  

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  28:09
• Aging

  Aging is an essential topic for the MCAT, and in this episode, we’ll explore it from multiple angles. We start with the biological aspects of aging, including key processes like telomere shortening, cell senescence, and mitochondrial dysfunction—each providing insight into how and why cells age. From there, we dive into how aging impacts the brain, including the types of memory and cognitive functions that either decline or improve with age. Lastly, we’ll cover the sociology of aging, focusing on the life course theory, the social significance of aging, and demographic changes. Expect a comprehensive breakdown of these concepts, with real-world applications and examples to reinforce your understanding. Visit MedSchoolCoach.com for more help with the MCAT.   Jump Into the Conversation: (00:00) Intro (02:30) Cellular markers of aging: Protein aggregation and telomere shortening (04:55) Exploring cell senescence and autophagy dysregulation (07:20) Mitochondrial dysfunction and its role in cellular aging (09:10) Deep dive into telomeres and the Hayflick Limit (12:30) Introduction to aging in the brain (13:45) Memory and cognitive functions that remain stable with age (15:30) Brain functions that improve as we age: Crystallized intelligence and emotional intelligence (17:00) Brain functions that decline with age: Episodic memory and processing speed (19:30) Causes of changes in brain function: Brain size, vasculature, and neurotransmitter levels (22:15) Introduction to the life course theory and its relation to aging (24:45) The social significance of aging in different cultures (26:00) The aging population and its impact on healthcare

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  30:51

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