MCAT Basics (from MedSchoolCoach)

• Population Genetics

  In this episode, we discuss population genetics and see how genetically related individuals share the same alleles, delving into the mechanisms of gene flow and genetic drift. We'll also unravel the complexities of hybrid vigor, reproductive isolation, and natural selection, and how these processes shape the genetic landscape of populations.    We'll also touch on the fascinating dynamics of X-linked and mitochondrial inheritance, and the role of genomic imprinting in disease risk. Ever wondered how the Hardy-Weinberg equation helps us understand genetic equilibrium in populations? We've got that covered too, breaking down the assumptions and applications of this essential model. Plus, we'll delve into how allele frequencies can shift due to factors like mutations and population bottlenecks.   Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: [00:00] Introduction to the MCAT Basics [01:06] Overview of Population Genetics [01:55] Definition of Population Genetics [03:01] Genotype vs. Phenotype [03:38] Example of BRCA1 Gene [07:33] Autosomal Dominant and Recessive Inheritance Patterns [08:40] X-Linked Inheritance Patterns [09:38] Mitochondrial Inheritance [10:46] Genomic Imprinting [12:46] Complex and Multifactorial Inheritance [13:52] Introduction to Hardy Weinberg Equation [14:33] Assumptions of Hardy Weinberg Equation [15:16] Historical Context of Hardy Weinberg Equation [17:02] Calculation of Allele Frequencies [19:18] Example Problem Using Hardy Weinberg Equation [23:17] Limitations of Hardy Weinberg Equation [24:07] Ways Populations Change Over Time [24:58] Natural Selection [27:10] Fecundity and Fertility in Natural Selection [28:07] Types of Natural Selection [30:00] Mutation [32:17] Example of Mutation in HIV Research [34:29] Genetic Drift [38:11] Gene Flow and Gene Leakage [40:12] Hybrid Vigor and Reproductive Isolation [42:16]  Prepare for MCAT success with MedSchoolCoach.

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• Common Hormone Axes

  In this episode, we'll explore three crucial hormone axes: the hypothalamic-pituitary-adrenal (HPA) axis, the hypothalamic-pituitary-gonadal (HPG) axis, and the renin-angiotensin-aldosterone (RAAS) system. We'll decode the complex interplays among the hypothalamus, pituitary gland, and various peripheral organs, focusing on how these hormone systems regulate everything from stress responses and reproductive functions to blood pressure and fluid balance. We'll break down the HPA axis and its pivotal role in stress response, featuring hormones like corticotropin-releasing hormone (CRH) and cortisol. Next, we’ll navigate through the HPG axis to understand the hormonal orchestration behind testosterone, estrogen, and progesterone production. Lastly, we’ll zero in on the RAAS system, demystifying its essential function in blood pressure regulation and electrolyte balance. Visit MedSchoolCoach.com for more help with the MCAT.  Jump into the conversation: [00:00] Introduction to the MCAT Basics Podcast with host, Sam Smith [03:11] Hypothalamus: brain section, regulates hormones, monkey bread. [08:57] Hypothalamus releases hormones to stimulate pituitary gland. [12:12] Cortisol is a crucial stress response hormone. [13:12] Steroid hormones need carrier proteins for transport. [17:05] Hypothalamic pituitary gonadal axis involves important structures. [21:01] Hypothalamus releases gonadotropin hormone for sex development. [27:14] Sex hormones regulate important body functions through feedback. [28:31] Juxtaglomerial cells respond to changes in blood pressure. [33:20] Angiotensin III and IV stimulate aldosterone release. [35:36] Renin angiotensin system increases sodium, blood pressure.  

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  39:10
• The Excretory System

  In this episode, we're covering the anatomy and physiology of key organs such as the kidneys, liver, skin, lungs, and large intestine, and discuss the crucial role they play in eliminating waste products from our bodies. From the structure of the hepatic lobules in the liver to the sweat glands in our skin and the alveoli in our lungs, we'll cover how each component functions to maintain homeostasis. We'll also delve into the metabolic breakdown processes and the excretion of waste molecules such as urea, electrolytes, and gases like carbon dioxide.  Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: [00:00] Introduction to the MCAT Basics Podcast with host, Sam Smith [04:50] Kidney, adrenal glands, nephrons filter blood. Bladder stores waste connected to kidneys. [09:57] Liver has lobes and functional hepatic lobules. Skin excretes through sweating. [12:20] Lung anatomy: trachea, bronchi, alveoli, gas exchange. [16:54] Urea cycle energy requirement, deamination of amino acids. [20:35] Urea density calculates volume of small ice cube. [24:15] Carbon dioxide is a metabolic byproduct. [27:46] Liver metabolizes drugs into water-soluble compounds.

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  30:24
• Sleep and Circadian Rhythms

  This episode is packed with essential high-yield information for your MCAT prep, covering the biological, physiological, and psychological aspects of sleep. We’ll explore various sleep theories, like the Memory Consolidation and Brain Plasicticity Theories, and even discuss the controversial “Sleeping When You Die” theory. We’ll also delve into dream theories, including Freud’s interpretations and the Activation Synthesys Hypothesis. Plus, we’ll address common sleep disorders such as insomnia, sleep apnea, and narcolepsy, alongside the effects of different drugs on your sleep patterns.    We’ll cover critical brain structures involved in sleep, such as the hypothalamus and the suprachiasmatic nucleus, and break down the stages of sleep measured through EEG, EMG, and EOG.    Visit MedSchoolCoach.com for more help with the MCAT.   [00:00] Introduction to the MCAT Basics podcast with host, Sam Smith [04:05] Pineal gland, amygdala, basal forebrain in sleep. [07:40] Measuring postsynaptic potential, not action potentials. EEG waves distinguish sleep stages. EMG records muscle electrical activity. [10:46] Alpha waves awake, theta waves asleep. Hallucinations in stage N1 sleep. [15:01] Unconfirmed sleepwalking. Stages of sleep explained. [18:18] Sleep cycles lengthen REM stage, diagrams illustrate. [19:50] We don't remember all our dreams. [23:55] Shifting circadian rhythms due to changes in light. [29:10] Blind people's melatonin release entrained with light. [29:41] Cortisol secretion cycle follows a circadian rhythm. [35:09] Freud: Dreams represent unconscious desires; manifest vs latent. [38:53] Divorce dreams related to spouse thinking time. Broad sleep disorder categories: insomnia, breathing, hypersomnolence. [41:18] Hypersomnia, narcolepsy, drugs' impact on sleep. [44:14 Brief primer on drug effects on sleep.  

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  45:39
• The Endocrine System

  In this episode, we’ll cover crucial aspects such as hormones, their origins and mechanisms of action, and the various structures within the endocrine system. We'll also decode complex cell-to-cell communication and distinguish between different hormone types—peptide, protein, steroid, and lipid-derived.   Furthermore, we'll explore key endocrine disorders like diabetes and hyper- and hypogonadism, discussing their causes, symptoms, and relevance to the MCAT. In addition, we'll touch upon the functions and hormones of several glands, including the pituitary, thyroid, adrenal glands, and pancreas.   Visit MedSchoolCoach.com for more help with the MCAT.   Jump into the conversation: 00:00 Introduction to the MCAT Basics Podcast with host, Sam Smith 03:34 Exosomes act as information carriers for cells. 09:00 Large, charged substances dissolve in blood easily. 10:30 Protein kinase A activates multiple molecules quickly. 15:57 Podcast discusses prostaglandin, thromboxins, leukotrienes and glands. 18:22 Hormones explained: flat peg and pineal gland. 23:15 Endocrine diseases: hyperthyroidism, hypothyroidism, hyperinhypogonadism, diabetes. 26:33 Autoimmune disorder characterized by overactive thyroid production. 29:28 Hypothalamus role in hormone production and disorders. 34:01 Type 1 diabetes: Genetic and environmental factors. 35:47 Diagnosis and causes of type two diabetes. 39:18 Med School Coach elevates your application level.  

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