Health Optimization Medicine Podcast

In this special in-person roundtable recorded in Washington, D.C., the HOMeHOPe faculty sit down to decode one of the most important perspective shifts in modern health: the Holobiont.
Moving away from the traditional, siloed medical model of "organology" (treating the heart, gut, and brain as isolated systems managed by different specialists), the faculty discusses why true health optimization requires viewing the human body as a complex, interconnected ecosystem of ecosystems.
Join us as we delve into:
The Holobiont Paradigm: Why you are not just a single organism, but a super-ecosystem made up of human cells and trillions of cooperating microbiota (including in your cornea, ureters, and gut).

The Danger of "Organ" Medicine: How specializing solely in individual organs leads to clinical blind spots, and why common prescriptions like statins and PPIs can quietly disrupt cellular energy (CoQ10) and nutrient absorption system-wide.

Metabolomics vs. Genetics: Why your DNA only tells you what might happen, while clinical metabolomics tells you exactly what is happening right now.

The Cell Danger Response (CDR): How your metabolites act as powerful epigenetic signalers, turning genes on and off to regulate systemic health and recovery.

The N-of-1 Future: Why large randomized controlled trials (RCTs) often fail by completely ignoring the gut microbiome, and why personalized, N-of-1 medicine is the only true path forward.

This episode is for you if:
You are tired of being bounced between specialists for interconnected symptoms like mood disturbances, fatigue, and chronic bloating.

You want to understand the limitations of DNA testing and why measuring real-time metabolites is the gold standard for biohacking.

You are a clinician looking to shift your practice from illness management to foundational cellular optimization.

You can also find this episode on…
YouTube: https://youtu.be/ILwab838zVM
Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
HOMeHOPe Conference: https://homehope.org/
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics
Find more from Troscriptions:
Website: https://troscriptions.com/
Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Health Optimization Medicine Podcast, the core faculty (Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz) tackles one of the most misunderstood topics in modern nutrition: fiber. Moving past the mainstream trend of "fiber-maxing," the team breaks down the actual biochemical realities of how different forms of fiber interact with your unique gut microbiome.
From the surprising hormonal impacts of over-consuming fiber to the rise of localized conditions, this roundtable shifts the conversation from generic dietary rules to precise, measurable, cellular data.
Join us as we delve into:
The Classification of Fiber: Understanding the biological differences between soluble fiber (which breaks down into calories) and insoluble fiber (which adds bulk to stool).

The Fiber Maxing Trap: Why forcing massive amounts of psyllium husk, acacia powder, and green drinks can aggravate conditions like Small Intestinal Bacterial Overgrowth (SIBO) and IBS.

The Estrogen Heist: The hidden clinical correlation between high-fiber diets (60g+ per day) and the cessation of menstruation (amenorrhea) in female athletes.

Short-Chain Fatty Acids (SCFAs): The crucial roles of propionate, acetate, and butyrate as genetic signalers and the primary fuel source for your large intestine.

The Gut as an Immune Organ: Why managing the "gut-associated lymphoid tissue" (GALT) forms the basis of roughly 80% of human immune system function.

This episode is for you if:
You are experiencing worsening gas, bloating, and discomfort despite eating a "clean, high-fiber" vegetarian or whole-food diet.

You want to learn how to test your stool for real-time butyrate levels instead of relying on generic probiotic protocols.

You want to understand how your unique gut ecosystem mirrors a complex, balancing rainforest.

You can also find this episode on…
YouTube: https://youtu.be/L5StNtmDrdg
Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/

Instagram: https://www.instagram.com/homehopeorg/

HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026

Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

Find more from Troscriptions:
Website: https://troscriptions.com/

Instagram: https://www.instagram.com/troscriptions/

Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Jup Kuipers, and Dr. Allen Bookatz reunite in person in Washington, D.C.. Moving away from traditional classifications of illness, the team breaks down a powerful paradigm shift: chronic disease and aging are not separate processes—chronic disease is aging.
Drawing from the pioneering frameworks of biogerontologist Aubrey de Grey and the SENS Research Foundation, they discuss how flawed metabolism inherently accumulates structural damage long before a clinical diagnosis ever appears.
Join us as we delve into:
•The Metabolism Flaw: How the very process keeping us alive produces reactive oxygen species and damage that eventually leads to tissue breakdown and pathology.
•Reclassifying Disease: Moving past the old congenital vs. infectious vs. chronic model to target metabolism directly.
•The $30,000 Stem Cell Mistake: Why dropping thousands on mesenchymal stem cells (MSCs) or exosomes is a waste of money if your body is trapped in a cellular defense posture.
•The Cell Danger Response (CDR): Understanding Robert Naviaux's work on how ancient defense mechanisms shut down growth and repair under stress.
•Morbidity Compression: Shifting your biology back to your optimal 21-to-30-year-old baseline to maximize healthspan and ensure you live vibrant before a rapid, peaceful end.
This episode is for you if:
•You want to understand why biohacking shortcuts like stem cells require metabolic priming to actually work.
•You are tired of "normal" lab ranges meant for a sick population and want true, age-optimized biomarkers.
•You want to stop guessing what vitamins or antioxidants your body needs and start measuring your exact metabolomic fingerprint.
You can also find this episode on…
YouTube: https://youtu.be/DygsezbmZxM 
Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics
Find more from Troscriptions:
Website: https://troscriptions.com/
Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Health Optimization Medicine Podcast, hosts Dr. Scott Sherr and Jodi Duval come together for an intimate, parent-to-parent roundtable. As the only current parents on the HOMeHOPe faculty, they dive deep into the specific biology of preconception, pregnancy, and pediatric health optimization. Moving beyond typical disease management, they explore how to foster both psychological and cellular safety across the entire family unit.
Join us as we delve into:
The Masterclass Blueprint: Navigating the fastest period of human growth and biological wiring from preconception to age 12.

The Energy Demands of Fertility: Why oocytes (eggs) and reproductive organs hold the highest mitochondrial density per cell in the body.

Pediatric Shifts: Addressing modern rises in childhood insomnia, allergies, immune dysregulation, and pediatric autoimmunity through an exposomic lens.

The Testing Trap: Why traditional adult lab testing templates aren't always required—or appropriate—for resilient, self-correcting children.

Family Attunement & Nervous System Regulation: Understanding why adult parent optimization directly dictates child behavior, sleep quality, and home environment stressors.

This episode is for you if:
You are a parent looking to leverage practical bioenergetics, chronobiology, and clean exposomics for your household.

You are preparing for pregnancy and want to optimize cellular health during the critical 90-day preconception timeline.

Your child is struggling with modern issues like appetite dysregulation, blue-light toxicity, or environmental heavy metal burden.

You want a sustainable template for family health that values parent self-care over self-sacrifice.

You can also find this episode on…
YouTube: https://youtu.be/WsvoFXcIuZ4
Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics 
Find more from Troscriptions:
Website: https://troscriptions.com/
Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty (Dr. Scott Sherr, Dr. Allen Bookatz, Dr. Ted Achacoso, and Dr. Jup Kuipers) dive deep into the unseen world inside your stomach. Moving beyond simple probiotics, they discuss the gut as a "post-natal organ" and explore how the trillions of microbes inside you actually dictate your cravings, your mood, and your immune system.
𝗝𝗼𝗶𝗻 𝘂𝘀 𝗮𝘀 𝘄𝗲 𝗱𝗲𝗹𝘃𝗲 𝗶𝗻𝘁𝗼:
•The "tripartite axis" (Gut-Brain-Enteric Microbiota) and how it links directly to treatment-resistant depression and anxiety.
•Why the vagus nerve is the master switch for your rest-and-digest parasympathetic nervous system.
•The concept of the "Holobiont": Why your microbial DNA is 100 times larger than your human DNA.
•How a single weekend of bad eating or a disrupted sleep schedule can completely derail your microbiome in just 72 hours.
•Why vegetarians sometimes struggle with massive bloating and methane gas production due to bacterial overgrowth.
𝗧𝗵𝗶𝘀 𝗲𝗽𝗶𝘀𝗼𝗱𝗲 𝗶𝘀 𝗳𝗼𝗿 𝘆𝗼𝘂 𝗶𝗳:
•You struggle with brain fog, anxiety, or treatment-resistant mood changes.
•You want to understand the actual mechanics behind "gut feelings" and sudden sugar cravings.
•You are tired of standard GI advice and want to learn how clinical metabolomics maps your microbiome.
•You want actionable steps to rebuild your gut ecosystem over the next 3 to 6 months.
𝗬𝗼𝘂 𝗰𝗮𝗻 𝗮𝗹𝘀𝗼 𝗳𝗶𝗻𝗱 𝘁𝗵𝗶𝘀 𝗲𝗽𝗶𝘀𝗼𝗱𝗲 𝗼𝗻… 
YouTube: https://youtu.be/2zhBdAHwuEU 
𝗙𝗶𝗻𝗱 𝗺𝗼𝗿𝗲 𝗳𝗿𝗼𝗺 𝗛𝗲𝗮𝗹𝘁𝗵 𝗢𝗽𝘁𝗶𝗺𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗠𝗲𝗱𝗶𝗰𝗶𝗻𝗲 𝗮𝗻𝗱 𝗣𝗿𝗮𝗰𝘁𝗶𝗰𝗲 (𝗛𝗢𝗠𝗲𝗛𝗢𝗣𝗲):
Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/
HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics
𝗙𝗶𝗻𝗱 𝗺𝗼𝗿𝗲 𝗳𝗿𝗼𝗺 𝗧𝗿𝗼𝘀𝗰𝗿𝗶𝗽𝘁𝗶𝗼𝗻𝘀: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products