Sounds of Science

• Breathing New Life into Toxicology: Human-Relevant Models in Action

  What if we could predict how chemicals affect human lungs without using animals? In this episode of Sounds of Science, Mary McElroy, Head of Discovery Toxicology and Pharmacology at Charles River, joins us to explore a groundbreaking collaboration with MatTek Life Sciences. Together, they’re pioneering human-relevant, non-animal models that could revolutionize inhalation toxicology. From 3D lung tissues to computational dosimetry, discover how science is catching its breath and moving toward a safer, more ethical future. Show NotesInhalation Toxicology | Charles River Mini Organs Offer Alternative Method for Predicting Drug Safety and Efficacy Alternative Methods Advancement Project | Charles River Charles River, in Collaboration with MatTek Corporation, Awarded Grant from the Foundation for Chemistry Research and Initiatives to Advance Research Alternatives 

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• Fighting For Liam - The Leston's Story

  For this episode I am joined by Megan and JC Leston, two parents who are fighting for their son Liam. The oldest of their five children, Liam was born with the rare Cri du Chat or 5p- syndrome. Through years of perseverance, they have created the Cri du Chat Research Foundation and started a movement to find a cure not only for Liam, but for all families affected by this genetic disease.Listen now to hear their story, and find out more about their work and how you can help at www.criduchatresearch.org.

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• Choosing Wisely: The Ethics, Science, and Emotion Behind Species Selection

  What if one decision could make or break your drug’s success? Join Charles River’s Sarah Gould as she unpacks the high-stakes, emotion-filled world of species selection—and why it’s about so much more than science. Discover how this critical choice shapes safety, speeds development, and drives innovation in today’s evolving research landscape.Show Notes Alternative Methods Advancement Project  | Charles River Animals in Research  | Charles River Research Models and Services | Charles River Research Animals Models | Charles River 

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• Supporting Mental Health for Veterans and First Responders: A Sabbatical Story

  Charles River scientist Nicole Hoekstra, herself a US Navy veteran, used her employer-supported sabbatical to help out local Oklahoma based nonprofit Inner Circle Mental Health, which focuses on aiding veterans and first responders who are struggling with their mental health. I am joined by Nicole and ICMH founder Kate Cooper to discuss what this service means to both of them, how we can support family who are reluctant to accept help, and how the COVID pandemic impacted the mental health of first responders. 

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• Little Monsters: How Microbes Manage At The Edge of Existence

  Ryan Cox from Microbial Solutions joins us to discuss the curious creatures living at the edges of life – from microbes pulled from the MIR space station to antibiotic resistant bacteria festering in shark mouths. Meet these and many more on this episode!

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