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This Week in Startups

Jason Calacanis
This Week in Startups
Latest episode

1377 episodes

  • This Week in Startups

    How These 3 Founders are building on Open Claw | E2248

    2026-2-12 | 45 mins.
    This Week In Startups is made possible by:

    Hubspot - http://clickhubspot.com/twist2

    Deel - http://deel.com/twist

    Iru - http://www.iru.com/

    Today’s show: 

    Today on TWiST we’re joined by 3 founders building on Open Claw,  Presh Dineshkumar, Vishnu, and Sean Liu!

    First, long time friend of the pod, Presh Dineshkumar, shows us how he’s using Open Claw to automate his work at The Wellness Company. His Open Claw agent, Eywa, lives in his email and in his product, able to compile user lists at his discretion.

    Then, we’re joined by Vishnu, who brings Open Claw to the masses. Non-technical folks, it’s your lucky day! Time to get Clawd-shotted! Last, Sean Liu joins the show to tell us about how he’s connecting Meta glasses to his Open Claw instance to interact with context that users can physically see!

    Timestamps:

    (0:00) We’re joined by Presh Dineshkumar of the Wellness Company, another OpenClaw fanatic

    (1:50) We meet Presh’s Replicant — Eywa — who spies on all of his emails

    (2:53) How Eywa is helping Presh keep track of his app’s most active users

    (4:35) LLMs have become very smart but they are trapped in the corner

    (6:10) How Presh gave Eywa its own email address and avoids prompt injections

    (8:56) Using Presh’s Replicant to do daily research dives

    (10:40) Hubspot: Check out the guide “Advanced ChatGPT Prompt Engineering: From Basic to Expert in 7 Days.” Download it for free at http://clickhubspot.com/twist2

    (13:21) Presh also has Eywa hunting down and fix bugs in his apps, all from email

    (16:16) Way more startups can be profitable now that they don’t need 10+ person teams

    (19:15) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.

    (20:36) We’re joined by two more OpenClaw builders: Vishnu and Xiaoan (Sean) Liu

    (21:16) Sean hooked his Meta Ray Bans up to his OpenClaw!

    (29:53) Iru unifies identity, endpoint security, and compliance into one platform. Book a demo at http://iru.com/

    (31:05) Some dystopian thoughts on how to use VisionClaw technology

    (32:47) What kinds of startups will get the most value out of OpenClaw?

    (34:43) Why Vishnu made a product to simplify OpenClaw set-up and security

    (37:34) What inspires people to stop considering OpenClaw and go “all in” on the tech

    (40:17) Will Vishnu and Sean quit their jobs and take Jason’s investment $125K investment deal… YES

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/

    Check out the TWIST500: https://twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    *

    Follow Lon:

    X: https://x.com/lons

    *

    Follow Alex:

    X: https://x.com/alex

    LinkedIn: https://www.linkedin.com/in/alexwilhelm/

    *

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/

    *

    Thank you to our partners:

    (10:40) Hubspot: Check out the guide “Advanced ChatGPT Prompt Engineering: From Basic to Expert in 7 Days.” Download it for free at http://clickhubspot.com/twist2

    (19:15) Deel - Founders ship faster on Deel. Set up payroll for any country in minutes and get back to building. Visit http://deel.com/twist to learn more.

    (29:53) Iru unifies identity, endpoint security, and compliance into one platform. Book a demo at http://iru.com/

    Check out all our partner offers: https://partners.launch.co/
  • This Week in Startups

    Does Clawdbot (OpenClaw) Need Eyes? (feat. Alex Finn and Matt Van Horn) | E2247

    2026-2-10 | 1h 7 mins.
    This Week In Startups is made possible by:

    LinkedIn - http://linkedin.com/twist

    Every.io - http://every.io/

    Northwest registered Agent - www.northwestregisteredagent.com/twist

    Today’s show: 

    Sean Liu gave his OpenClaw “eyes” by hooking the AI assistant up to his Meta Ray Bans. While Jason and Alex consider the implications… guest expert Alex Finn quickly loses interest…

    It’s another All-Clawdbot TWiST where we debate the most essential uses for the viral agent platform. For their part, Alex Finn and Matt Van Horn are building practical skills to help founders (esp. solo founders)… Alex has a brain trust of AI agents working round the clock to improve his organization and content, while Matt designed a skill for his agent to order sushi lunches (keeping them under $20).

    PLUS find out how Producer Oliver designed his “Model Council” based on Perplexity’s set-up, why running everything local is “illogical” for most people in 2026, AND why Jason’s next Founder U cohort will all be building with OpenClaw.

    Timestamps: 
    (00:00) Why Jason is STILL Claw-pilled! We can’t get enough!
    (03:17) “Mr. Clawdbot” Alex Finn of Creator Buddy joins us! He’s Claw-Pilled too!
    (04:50) Sean Liu (@_seanliu) added OpenClaw to his Meta Ray Bans… Here’s why Alex doesn’t care!
    (8:33) Lost your job to AI? Maybe AI can make you a founder!
    (12:35) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.
    (13:34) “Last 30 Days” skill creator Matt Van Horn (@mvanhorn) joins the show
    (14:54) Why Jason wants to invest in Matt’s new project.
    (15:53) Meeting Alex’s organization of AI agents who collaborate on his projects autonomously
    (22:28) Is Alex planning to turn his OpenClaw set-up into a company? Maybe…
    (23:10) Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit http://every.io/
    (25:16) Using OpenClaw to create a “lights out” startup
    (28:17) Deciding when to use local models vs. more powerful cloud-based models
    (29:52) Northwest Registered Agent. Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at www.northwestregisteredagent.com/twist
    (30:58) How Producer Oliver created a “Model Council” for LAUNCH based on Perplexity’s set-up
    (35:52) Why it’s so important to have an orchestrator that knows the right model for the right task
    (39:12) Why running everything local is “illogical” for most companies in 2026
    (41:15) Matt walks us through the latest and greatest incarnation of his “Last 30 Days” skill
    (45:57) Why Jason thinks recursive machine learning is the solution to human laziness
    (46:38) How Alex has supercharged his social media and his startup during OpenClaw Mania
    (50:15) Why Founder University is going ALL OPENCLAW next cohort
    (51:21) How big a jump over Opus 4.5 is Opus 4.6?
    (53:35) OpenClaw’s going to start scanning skills for malware… Will this help?
    (57:13) No one was SUPER impressed by the AI dot com Super Bowl ad… except JCal
    (1:01:11) Matt used his “Order Sushi” OpenClaw skill live on the show to get lunch
    (1:04:08) Polymarket’s sharps are wagering on Claude 5’s hotly anticipated release

    Thank you to our partners:
    (12:35) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.
    (23:10) Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit http://every.io/
    (29:52) Northwest Registered Agent. Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at www.northwestregisteredagent.com/twist

    Check out all our partner offers: https://partners.launch.co/
  • This Week in Startups

    We built OpenClaw Ultron to replace 20 people at our company | E2246

    2026-2-07 | 1h 10 mins.
    This Week In Startups is made possible by:

    Crusoe Cloud - https://crusoe.ai/savings

    Lemon IO - https://Lemon.io/twist

    Northwest Registered Agent - https://www.northwestregisteredagent.com/twist

    Thanks to our guests:

    Alex Cheema of ExoLabs http://exolabs.net

    Ryan Yanneli of NextVisit https://nextvisit.ai/

    Today’s show: 

    It’s the Age of Ultron at TWiST and LAUNCH. We’ve given our OpenClaw digital Replicants the keys to all of our systems and we’re seeing how much of our jobs they can really do when left to their own devices.

    Producer Oliver stops by the show to give us a peek behind the curtain, at the new control panel and dashboard OpenClaw built FOR ITSELF (with a bit of human assistance).

    PLUS we’re joined by Alex Cheema of ExoLabs. His company helps everyday consumers run powerful frontier LLMs on their own devices, essential to protect your data and personalize your AI experience.

    ALSO congratulations to Ryan Yanneli from NextVisit on winning our Gamma Pitch Deck Competition! He walks away with $25K from LAUNCH and our friends at Gamma.

    Timestamps:

    (00:00) Introducing Alex Cheema to the show

    (3:17) Why it is so important to run AI on local hardware

    (6:58) Using OpenClaw Producer to automate TWiST

    (8:59) How to Train your AI

    (11:58) What is a Chron Job? (Hint: chron means chronological)

    (13:24) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.

    (17:53) OpenClaw managing the LAUNCH/TWiST team

    (19:54)  Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist

    (20:58) Turning AI into Ultron, self optimization

    (27:21) The Future: frontier models: running on your Iphone!

    (28:37) Prompt injections: how people can hack your OpenClaw

    (30:25) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at https://www.northwestregisteredagent.com/twist

    (31:31) OpenClaw invites guests that join the show

    (40:29) Oliver shows off OpenClaw mission control dashboard

    (46:30) Stacking Apple Silicon vs. Running Kimi-K

    (50:18) How Exo Labs works — stringing together Mac Silicon

    (54:29) Ryan from Nextvisit wins Gamma Pitch Competition

    (59:10) Industry Season 4 reflects tech regulation

    *

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

    Check out the TWIST500: https://www.twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    *

    Follow Lon:

    X: https://x.com/lons

    *

    Follow Alex:

    X: https://x.com/alex

    LinkedIn: https://www.linkedin.com/in/alexwilhelm/

    *

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/

    *

    Thank you to our partners:

    (13:24) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/savings to reserve your capacity for the latest GPUs today.

    (19:54)  Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist

    (30:25) Northwest Registered Agent - Get more when you start your business with Northwest. In 10 clicks and 10 minutes, you can form your company and walk away with a real business identity —  Learn more at https://www.northwestregisteredagent.com/twist

    Check out all our partner offers: https://partners.launch.co/
  • This Week in Startups

    Savvy is HQ Trivia + Wordle (feat. Scott Rogowsky) | E2245

    2026-2-04 | 53 mins.
    This Week In Startups is made possible by:

    Circle - http://Circle.so/twist

    Caldera Lab - http://calderalab.com/TWIST

    LinkedIn - http://linkedin.com/twist

    Today’s show: 

    There was a time, not long ago, when offices everywhere came to a standstill, and everyone became even more fixated on their phones than usual, each time HQ Trivia went live. The app-based game show was a massive viral hit… until suddenly, around a year later, it wasn’t.

    Now, HQ Trivia host Scott Rogowsky is back with a new concept: Savvy, another game show you play on your phone, this time inspired by the word puzzle hit Wordle. Is lightning about to strike twice? 

    PLUS, Alex chats with Trevor Bennett of space transportation outfit Starfish Space. This comes off two major successes for the team: the Remora mission that proved Stafish’s autonomous rendezvous capabilities and the $52.5 Million dollar contract to dispose of low Earth orbit satellites.

    Timestamps: 

    (00:00) How Scott first got involved with HQ Trivia

    (2:23) Why Scott thinks HQ Trivia struck such a chord with fans

    (4:12) Scott couldn’t get a job in late night, so he made his own show

    (5:31) Delving into the behind-the-scenes tensions at HQ Trivia

    (11:07) Circle -  the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to http://Circle.so/twist

    (13:53) The end of HQ Trivia and why Scott jumped ship

    (16:35) Savvy just had its series premiere: you play the game against the host

    (20:14) How to play Savvy and win cash

    (20:57) Why Jason thinks a subscription model is the future of Savvy

    (22:25) Whether you’re starting fresh or upgrading your routine, Caldera Lab makes skincare simple and effective. Head to http://calderalab.com/TWIST and use TWIST at checkout for 20% off your first order.

    (23:31) Introducing Dr. Trevor Bennet of Starfish Space

    (24:04) What the Otter Spacecraft does: de-orbiting to clean up space

    (26:46) Why space will need hundreds of Otters in space

    (29:24) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.

    (30:23) Starfish Space’s business model: operating a starfleet

    (33:17) The success of the Remora mission: autonomous rendezvous in space.

    (43:47) The rise of the space economy

    (48:18) Starfish’s $52.5 Million dollar contract and what it means for the space ecosystem

    *

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/

    Check out the TWIST500: https://twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    *

    Follow Lon:

    X: https://x.com/lons

    *

    Follow Alex:

    X: https://x.com/alex

    LinkedIn: https://www.linkedin.com/in/alexwilhelm/

    *

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/

    *

    Thank you to our partners:

    (11:07) Circle -  the easiest way to build a home for your community, events, and courses — all under your own brand. TWiST listeners get $1,000 off the Circle Plus Plan by going to http://Circle.so/twist

    (22:25) Whether you’re starting fresh or upgrading your routine, Caldera Lab makes skincare simple and effective. Head to http://calderalab.com/TWIST) and use TWIST at checkout for 20% off your first order.

    (29:24) LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at http://linkedin.com/twist Terms and conditions apply.

    Check out all our partner offers: https://partners.launch.com
  • This Week in Startups

    Where early-stage founders MUST focus to success | E2244

    2026-2-03 | 1h 7 mins.
    This Week In Startups is made possible by:

    Quadratic - http://quadratic.ai/twist

    Today’s show: 

    Don’t get distracted! Here are the MOST CRUCIAL aspects of running a startup, where founders need to keep their full and uninterrupted focus.

    - Make sure you’re saving up your cash
    - Why you need to just get started and build SOMETHING
    - Trust and reliability is EVERYTHING for new products
    - Why distribution should be your top priority

    Download all this practical and tactical startup advice from seasoned veterans Jason Calacanis, Amanda Bradford, and William P. Barnes in this Tokyo edition of TWiST.

    Timestamps:

    (00:00) Amanda and Will’s big takeaways from Founder U in Saudi Arabia and now Tokyo

    (3:19) Why cash flow management is so important before you find PMF

    (5:57) Why first-time founders get the order of operations wrong

    (6:45) Just build SOMETHING, even if it’s taped together

    (11:19) “Focus is everything in the early stages”

    (14:17) From a wedge to a bridge

    (15:50) Quadratic - Bringing the productivity boost of AI into your spreadsheets. Visit http://quadratic.ai/twist to sign up and use the code TWIST to get one free month of their pro tier subscription.

    (18:45) What to put on your “Not Right Now” list

    (19:11) Embracing simplicity

    (22:00) The importance of trust and reliability (especially for Uber!)

    (28:12) Why innovation needs a constraining variable

    (33:40) To really drive word of mouth, you have to overdeliver

    (36:32) Distribution is the primary job of a founder/CEO

    (38:19) Some of the panel’s favorite distribution hacks

    (45:54) Why Jason respects Japan’s commitment to excellence and competency

    (49:38) Looking for “high slope” in early employees

    (53:11) Transitioning your team from early-stage startup to growth

    (57:45) Whoever writes it down gets credit for the idea

    (58:04) Q: Has the meaning of money changed for the panel now that they’ve had successful exits?

    *

    Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com/

    Check out the TWIST500: https://twist500.com

    Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

    *

    Follow Lon:

    X: https://x.com/lons

    *

    Follow Alex:

    X: https://x.com/alex

    LinkedIn: https://www.linkedin.com/in/alexwilhelm/

    *

    Follow Jason:

    X: https://twitter.com/Jason

    LinkedIn: https://www.linkedin.com/in/jasoncalacanis/

    *

    Thank you to our partners:

    (15:50) Quadratic - Bringing the productivity boost of AI into your spreadsheets. Visit http://quadratic.ai/twist to sign up and use the code TWIST to get one free month of their pro tier subscription.

    Check out all our partner offers: https://partners.launch.co/

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About This Week in Startups

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.
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