Cheeky Pint

John Collison and Dwarkesh Patel sit down with Elon Musk to discuss why the future of AI isn’t on Earth, but in the "always sunny" vacuum of space. Between pints, they discuss the brutal physics of scaling—from the "farcically cheap" solar cells coming out of China to switching Starship from carbon fiber to stainless steel—as well as the “infinite money glitch” of humanoid robots, China, and DOGE.

Timestamps
00:00:23 Space GPUs
00:35:39 Alignment
00:58:48 xAI
01:15:01 Optimus
01:28:03 China
01:40:46 Management
02:16:38 DOGE
02:34:58 Space GPUs redux

Julia DeWahl is the cofounder of Antares, a company developing nuclear micro-reactors for the US military and critical infrastructure. She sits down with John to discuss the vision for the "Starlink of electricity", and why AI hyperscalers are driving a nuclear renaissance. They cover the bipartisan shift in nuclear regulation (and why the NRC’s old mandate made "zero" the safest number of reactors), and why true energy resilience requires more than just solar and batteries. Julia also shares lessons from the early days of Opendoor and Starlink, including why customer obsession sometimes means sitting outside a bagel shop.
Timestamps
(00:00) Lessons from SpaceX and Opendoor
(02:46) Introducing Antares
(06:30) The path to market
(12:20) Nuclear vibe shift
(15:11) Regulation
(19:21) Possible energy futures
(24:02) Stripe Radar
(24:55) Nuclear supply chains
(26:43) Antares origin story
(30:24) Funding Antares
(36:09) If Julia was energy tsar
(42:33) Restarting shuttered plants

Satya Nadella, CEO of Microsoft, sits down with John to discuss the diffusion of AI inside the enterprise. He explains why “all your data at your fingertips” is the evergreen pitch, why this AI CapEx cycle is different from the .com bubble, and his vision for "agentic commerce". They also cover Microsoft's product bundling strategy and how he "wanders the virtual corridors" of Teams to run the company.

Links
[Read] Softwar: An Intimate Portrait of Larry Ellison and Oracle, Matthew Symonds
[Try] Superwhisper
[Read] The Internet Tidal Wave, Bill Gates

Timestamps
(00:00) AI adoption in the enterprise
(07:47) How Satya runs Microsoft
(13:45) New UIs
(20:44) Microsoft tackling the early internet
(25:58) Are we in a bubble?
(31:35) Data sovereignty
(38:10) Excel
(42:01) Agentic commerce
(52:45) AI brand loyalty
(59:44) Product bundling
(01:08:18) Microsoft’s culture
(01:12:12) The law of very large companies
(01:16:20) What’s in the water in Hyderabad?

Dave Ricks, the CEO of Eli Lilly, the world's most valuable pharmaceutical company, sits down with John and Patrick to discuss the complex business of drug development. Dave explains the true origin story of GLP-1s (from Gila monster saliva), why their potential goes far beyond weight loss to addiction and inflammation, and how "self-pay" has become the #1 way new patients get Zepbound. They cover the "shadow generic" industry undermining patents, the challenges associated with clinical trial enrollment, and what drove insulin list prices to $275 (while the net price was $40). This is a rare, candid look into the strategies, science, and future of pharma from one of the industry's most influential leaders.
Timestamps
(00:00) Introducing Dave Ricks
(05:07) Making R&D decisions
(10:10) Clinical trials
(24:59) Drug pricing
(32:43) Stimulating more R&D
(54:15) Pros and cons of US healthcare
(58:20) New pharma business models
(01:05:53) Stripe and enterprises
(01:07:00) China
(01:16:31) Generics
(01:22:37) GLP-1s
(1:37:43) r/Peptides
(01:41:25) LillyDirect
(01:46:35) Why do investors love LLY?

Zach Abrams, the CEO and cofounder of Bridge, the leading stablecoin orchestration platform, and Henri Stern, CEO and cofounder of Privy, the leading crypto wallet infrastructure, sit down with John to discuss the future of stablecoins, issuing, and what it will take for crypto to become ubiquitous. Both companies recently joined Stripe, and are uniquely positioned to dissect how crypto is changing financial infrastructure.
Key moments
(00:00) Introducing Bridge + Privy
(06:39) How stablecoins are being used today
(14:27) US Dollar dominance
(25:50) The future of banking
(34:35) Blockchains
(42:27) Building a modular stack
(47:14) Open issuance
(56:55) M&A
(01:11:02) The future of stablecoins