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Solve for X: Innovations to Change the World

MaRS Discovery District
Solve for X: Innovations to Change the World
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  • It’s different all over: Embracing the complexity of human biology
    By uncovering critical sex-based differences related to brain and metabolic health, researchers Gillian Einstein and Minna Woo are making the case that tailored interventions are key to improving health outcomes for women — and everyone else. Through their work exploring how conditions from Alzheimer’s to kidney disease can have varied effects depending on a patient’s sex, they underscore what the medical community as a whole can learn from experts in women’s health: Things aren’t as simple as we want to believe. In this bonus episode, recorded live on May 8, 2025, at the MaRS Impact Health Conference, Einstein and Woo discuss the complexity of biology, the challenges of funding and why they’re optimistic that things are changing.Featured in this episode:Gillian Einstein is the Wilfred and Joyce Posluns Chair in Women’s Brain Health and Aging and a psychology professor of psychology at the University of Toronto. She’s also an adjunct scientist at Baycrest and Women’s College Hospitals, and an honorary doctor of medicine at Linköping University, Sweden. Her lab’s current focus is on estradiol loss as well as how stigma and immigration affect memory and cognition in diverse populations of women.Minna Woo is currently the director of the Banting and Best Diabetes Centre at the University of Toronto and recently completed a 10-year term as division director of endocrinology and metabolism at the Toronto General Hospital, University Health Network (UHN). She now holds the Ajmera Chair in Molecular Diabetes Research at the Toronto General Hospital Research Institute and is a clinician scientist and a staff endocrinologist providing diabetes and endocrine care at UHN. Her laboratory focuses on molecular mechanisms that determine the pathogenesis of insulin resistance and related diseases. She has published more than 100 research articles and her research is internationally recognized as a member elect of the American Society of Clinical Investigation.Katherine Ward is an award-winning journalist currently working with Global News in Toronto. She joined the team in 2018 and has covered a wide range of stories taking her all over Ontario. This year, Ward was also part of an investigative team that exposed the prevalence of lead contamination in drinking water. “Tainted Water” went on to win a national award with Canada’s Radio Television Digital News Association.Further reading: • From body to brain: Understanding how sex and gender contribute to brain health as we age• More women get Alzheimer’s than men. It may not just be because they live longer• Sleep quality and the menstrual cycle• Breaking down sex and gender barriers in search of precision medicine• Canada accelerates diabetes researchSubscribe to Solve for X: Innovations to Change the World here.  Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.
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  • Cold comfort: How to keep cool without destroying the planet
    The hotter it gets outside, the more we use air conditioning, and the more we use air conditioning, the hotter it gets. AC units and refrigeration combined adds up to 10 percent of global greenhouse gas emissions. But how can we solve this cooling paradox? Building on last episode’s conversation with the UN’s global chief heat officer, host Manjula Selvarajah meets the experts harnessing novel innovations to keep cities and people cool — from massive infrastructure projects using ice-cold lake water to microscopic solutions to get rid of that sticky, sweltering humidity. David MacMillan is a manager in the City of Toronto’s Environment, Climate and Forestry division. He and his team are focused on planning for low-carbon development and energy systems, which includes implementing the Toronto Green Standard, which aims for net-zero new buildings by 2028, and renewable energy programs such as SolarTO and Wastewater Energy.  Cameron Leitch is the director of solutions and innovations at Enwave Energy Corporation, which oversees the largest deep lake water cooling (DLWC) project in the world. Pulling near-freezing water from the depths of Lake Ontario, this massive infrastructure system provides alternative cooling to more than 100 buildings in downtown Toronto, including arenas, condos, offices, data centres and hospitals — a clean energy initiative that has been recognized by the United Nations. Evelyn Allen is the co-founder of Evercloak, a Waterloo-based company that has developed graphene oxide membranes that helps to dehumidify air before it reaches AC and HVAC units, significantly reducing the energy and refrigerants needed to cool a space. The company is currently part of the Mission from MaRS: Better Buildings Adoption Accelerator program. Daniel A. Barber is a professor of architecture and the environment at Eindhoven University of Technology in the Netherlands. Barber’s research and work focuses on how changing temperatures have altered our built environment, and how architects can help adapt to the climate crisis. At architecture symposium Biennale Venice, his interactive installation, “Terms and Conditions,” allowed participants to experience the stifling effects of the waste heat that air conditioning units produce. Further reading: Air conditioning poses a climate conundrumToronto company using lake water to cool buildings expands systemToronto is home to the world’s largest lake-powered cooling system. Here’s how it works.Air conditioners fuel the climate crisis. Can nature help?How to build an AC that will get the world through hotter summersA rebuke to Modernism: the Venice Architecture Biennale imagines new ways of building to cope with climate changeSubscribe to Solve for X: Innovations to Change the World here.. Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.
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  • Heat warning: Are we ready for a hotter climate?
    Extreme heat waves are anything but normal, but they’re quickly becoming the new reality. The 10 hottest years on record have all happened in the last decade. And because temperatures in urban centres can be 10 to 15 degrees Celsius higher than surrounding areas, cities can be dangerous places to be when the mercury rises — particularly for the elderly, those with pre-exisiting health conditions as well as poorer populations who lack access to air conditioning. “Heat has a way of going through the city and finding those who are the weakest,” says Eleni Myrivili, the United Nations’ global heat officer. “It’s a very unfair climate condition.” In this episode, we explore the growing risk posed by heat and what could help us adapt to a hotter world. Eleni Myrivili is the United Nation’s first-ever global chief heat officer. An anthropologist by training, Myrivili understands how heat waves discriminate against older, less-wealthy and under-served demographics. Before being named to her UN post in 2022, Myrivili was Athens’ heat officer, where she coordinated the capital’s response to heat waves and helped renovate an ancient Roman aqueduct to bring water into the city.Further reading: What will it take to save our cities from a scorching futureEarth’s 10 hottest years on record are the last 10Extreme heat is deadlier than hurricanes, floods and tornadoes combinedHeat inequality ‘causing thousands of unreported deaths in poor countries’The heat crisis is a housing crisisAncient civilizations countered extreme heat. Here’s what cities borrow from historyToronto's getting hotter. Experts say a chief heat officer could help the city adaptArchitects turning to India’s lattice-building designs to keep buildings cool without air conditioning How India’s lattice buildings cool without air conditioningAthen’s answer to a water supply crunch: an ancient aqueduct  Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.
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  • Regrowth strategy: To adapt to a changing climate, restoring nature is critical. But do we have the seeds we need?
    A quarter of Canada’s trees are at risk, and upwards of a million species around the world face extinction in the decades to come. Restoring nature is essential to survival — it can make communities more resilient to climate change, it can regrow areas destroyed by increasingly intense wildfires and it can help reduce atmospheric carbon. But repairing ecosystems is not as simple as planting seeds. In this special episode, experts weigh in on restoration efforts, the global seed storage and why there’s such a thing as planting too many trees. Featured in this episode: Martina Albert is a technician with the National Tree Seed Centre, based in Fredericton, N. B. The NTSC’s library holds more than 13,000 seed collections, with the purpose of protecting them from invasive pests, disease and climate change. Albert works on the Centre’s Indigenous Seed Collection Program, working with First Nations communities to collect and preserve tree seeds for generations to come. Blaine Pearson is the CEO of Seedark, a climate tech venture that is working to modernize the global supply chain of seeds. Its app, Squirrel, connects growers and reforestation experts with seed collectors, while digitally tracking where seeds are coming from. Pearson has more than 20 years of entrepreneurial experience, focusing on harmonizing the application of technology with environmental protection, and is currently part of the RBC Women in Cleantech Accelerator. Faisal Moola is an associate professor in the department of geography, environment and geomatics at the University of Guelph. Moola oversees research on the ecology and ethnoecology of cultural keystone species with Indigenous Peoples here in Canada and around the world. Jim Robb is the general manager of the Friends of the Rouge Watershed. The organization partners with communities and volunteers to protect and restore ecosystems, with a focus on Rouge National Urban Park. Robb helps organize nature walks, community planting events and educational programming to inspire the next generation of ecological stewards. D’Amour Walker is the assistant project coordinator at Friends of the Rouge Watershed, where she ensures trees, shrubs and plants are in healthy condition as part of the reforestation and ecosystem restoration efforts. Further reading: Saving nature: WWF study highlights the best places for ecological restoration in CanadaWanted: tree seeds. National seed centre in Fredericton collecting samplesIndigenous Seed Collection Program begins cross-country journey in FrederictonWe need native seeds in order to respond to climate change, but there aren’t enoughWhy Indigenous peoples are raising the alarm on carbon trading at UN climate summitGrasslands store tons of carbon — and there’s a movement to protect themBiodiversity or bust? Here’s what happened at COP16What you need to know about nature-based solutions to climate changeSubscribe to Solve for X: Innovations to Change the World here.  Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.
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  • Compounding the cure: How our overzealous efforts to zap infections could be making animals — and humans — sicker
    Experts are calling antimicrobial resistance the silent pandemic: Each year, AMR is responsible for more than a million deaths around the world. It’s a threat to our health that’s been exacerbated by the very medications used to treat it. This problem has been growing for decades, and healthcare practitioners have responded by developing new antibiotics. “And then,” says Dr. Scott Weese, a global expert in antimicrobial resistance, “we started running out of antibiotics.” To address the rise of drug-resistant pathogens, we need to examine how we use these medications to treat disease in both humans and animals, says Weese. The question is, how can we safeguard the life-saving drugs we have — while also protecting the health of all creatures on this planet?Featured in this episode: Dr. Scott Weese is a veterinary internal medicine specialist, chief of infection control and director of the Centre for Public Health and Zoonoses at the University of Guelph’s Ontario Veterinary College. Weese is a member of the Global Leaders Group on antimicrobial resistance and has helped craft antimicrobial use guidelines for veterinarians in Canada. Further reading: The global threat of antibiotic resistanceAt the UN, world leaders are negotiating the biggest health issue you’ve never heard ofThree million child deaths linked to drug resistance, study showsDo I need that antibiotic?Veterinary medicine is key to overcoming antimicrobial resistanceThe link between pets, people and antimicrobial resistanceCanada introduces new guidelines to tackle antimicrobial resistance Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.
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About Solve for X: Innovations to Change the World

Solve for X uncovers what’s next. Join journalist Manjula Selvarajah as she dives into the latest tech innovations shaping our world. How are satellites revolutionizing the fight against climate change? Could music be the medicine we need? What will it take for Canada to lead the global tech scene and achieve a zero-emission future? Discover the answers to these questions and more in the next season of Solve for X.
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