The Popkin Method

Welcome back to The Popkin Method, where we connect symptoms to science, and science to solutions. In today’s episode, we're tackling one of the biggest blind spots in modern medicine: perimenopause and menopause. Millions of women are told their labs are normal while silently struggling with fatigue, anxiety, weight gain, sleep disruption, and a loss of vitality. But what if these symptoms aren’t random? What if they’re actually signals from your body?
Dr. Matthew C. Popkin breaks down the complex physiologic transition of midlife hormonal change and reveals how the Popkin Method offers a systems-based, whole-body approach. We’ll dive into lifestyle medicine, nutrition, exercise, strategic supplementation, hormone modulation, peptides, regenerative medicine, and the science of longevity. If you’ve ever felt dismissed or misunderstood during this phase of life, or you want a better strategy than band-aid solutions and social media fads, this episode is for you. Let’s get started and redefine what thriving through menopause can look like.

Timestamps:
00:00 Understanding menopause and the Popkin method
06:07 Weight gain frustrations and body changes
06:57 Menopause and weight gain issues
12:28 Diet tips for maintaining muscle
16:06 Choosing quality supplements
19:15 Importance of individualized hormone therapy
22:00 Importance of Testosterone in Women
26:44 Testosterone therapy options for women
27:47 Testosterone treatment methods and issues
31:29 Benefits of Testosterone Therapy
33:57 Testosterone and breast cancer risk
37:47 Testosterone therapy side effects
42:33 Discussing peptide treatments and benefits
44:47 Discussing GLP-1 medications usage
48:01 Discussing regenerative medicine basics
52:07 Discussing effective menopause treatments
54:22 Discussing women's health and longevity

You can see Dr. Popkin through his online virtual functional medicine program anywhere in the country or the world for that matter.
You can visit Dr. Popkin in his Hollywood Florida office for an in person weight loss experience.
Visit thepopkinmethod.com to send a message to schedule an appointment with Dr. Popkin or email Dr. Popkin at mcpopkinmd@yahoo.com.
Podcast Website - https://thepopkinmethod.com/
Matthew C. Popkin, M.D. - https://thepopkinmethod.com/about
Podcast Partner - TopHealth - https://tophealth.care/
“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Welcome to The Popkin Method, where we cut through the noise of miracle weight loss solutions and trendy shortcuts dominating social media and advertising today. In this episode, Dr. Matthew C. Popkin takes a deep, clinical dive into GLP-1-based therapies like semaglutide and tirzepatide, some of the most talked-about tools in modern medicine. But here’s the catch: these medications aren’t magic fixes. Instead, Dr. Matthew C. Popkin unpacks the importance of a comprehensive, sequenced approach that prioritizes lifestyle optimization, strategic nutrition, resistance-based training, and targeted supplementation before even considering medication.
We’ll explore why so many struggle to keep weight off after stopping these peptides, why even lean individuals can battle insulin resistance, and how stacking the right peptides with solid foundational habits creates sustainable results. This isn’t about chasing the next health trend, it’s about reclaiming control of your physiology and building a system that actually works for the long-term. Let’s get into it.

Timestamps:
00:00 Success with GLP1 weight loss peptides
03:58 Critiquing wellness influencer marketing
10:22 Navigating modern marketing challenges
11:57 Supervised weight loss and lifestyle changes
14:42 Understanding Skinny Fat and Metabolic Health
19:29 Prioritize fiber and healthy fats
21:46 Spacing Protein Intake
26:23 Maintaining Muscle with Diet and Exercise
28:22 GLP1 therapies and liver health
32:50 Prepping your body for medication
34:20 GLP1 Medication Reset Protocol
37:31 Peptide stacking with physician guidance
40:54 Choosing the right peptides
46:51 Addressing Insulin Resistance Strategies
50:47 Avoiding medication dependency
53:22 Understanding the Popkin Method
55:04 Introduction to the Popkin Method

You can see Dr. Popkin through his online virtual functional medicine program anywhere in the country or the world for that matter.
You can visit Dr. Popkin in his Hollywood Florida office for an in person weight loss experience.
Visit thepopkinmethod.com to send a message to schedule an appointment with Dr. Popkin or email Dr. Popkin at mcpopkinmd@yahoo.com.
Podcast Website - https://thepopkinmethod.com/
Matthew C. Popkin, M.D. - https://thepopkinmethod.com/about
Podcast Partner - TopHealth - https://tophealth.care/
“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Welcome back to The Popkin Method! In today’s episode, Dr. Matthew C. Popkin tackles one of the most misunderstood, yet critical, obstacles to lasting weight loss and wellness: fatty liver disease. Most people think of it as just a byproduct of poor diet or being overweight, but as you’ll learn today, fatty liver is actually a hidden metabolic bottleneck that could be sabotaging your best efforts to get healthy.
If you’ve ever felt inexplicably stuck with your weight, tired for no clear reason, frustrated by slow progress even with medications, or overwhelmed by conflicting health advice online, this episode is for you. Dr. Matthew C. Popkin will break down what fatty liver disease really is, why it develops silently, and most importantly, how his signature four-phase Popkin Method can help you reverse it with a sustainable, physician-guided approach that goes far beyond gimmicks, fad diets, or quick fixes.
We’ll cover the common symptoms, the pitfalls of “magic bullet” solutions, and exactly which steps you need to take, from food choices and sleep, to advanced therapies, to restore your liver health, unlock your metabolism, and finally achieve lasting change. Whether you’re new to The Popkin Method or following along since episode one, you’ll walk away with a clear, actionable blueprint to take control of your health.
Ready to cut through the noise? Let’s dive into the truth about fatty liver disease and discover how to get truly unstuck.

Timestamps:
00:00 Understanding fatty liver disease
09:57 Understanding fatty liver and GLP1 meds
14:04 Supporting fat utilization strategies
19:21 Understanding fasting and diet choices
25:06 Common intermittent fasting mistakes
30:07 Replacing carbs with veggies and fats
36:32 Anti-inflammatory foods and coffee benefits
37:44 Choosing the right protein shake
47:04 Trustworthy supplements for fatty liver
50:05 Discussing stem cell therapies
59:29 Hormone modulation with supplements
01:03:48 Steps for improving liver health
01:09:32 Understanding the Popkin Method
01:11:14 Sharing The Popkin Method

You can see Dr. Popkin through his online virtual functional medicine program anywhere in the country or the world for that matter.
You can visit Dr. Popkin in his Hollywood Florida office for an in person weight loss experience.
Visit thepopkinmethod.com to send a message to schedule an appointment with Dr. Popkin or email Dr. Popkin at mcpopkinmd@yahoo.com.
Podcast Website - https://thepopkinmethod.com/
Matthew C. Popkin, M.D. - https://thepopkinmethod.com/about
Podcast Partner - TopHealth - https://tophealth.care/
“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Welcome back to The Popkin Method! In this episode, Dr. Matthew C. Popkin takes us beyond the surface of anti-aging, exploring the science of aging from the inside out. We’re all familiar with visible signs like wrinkles and graying hair, but what really drives aging happens deep within our cells. Dr. Matthew C. Popkin uncovers the critical role of mitochondrial function and the powerful molecule NAD, revealing how their decline accelerates aging and chronic disease.
You’ll learn why energy production at the cellular level is at the heart of longevity, how lifestyle choices like diet, sleep, and exercise can naturally support NAD, and which trendy supplements may be less effective than you think. We’ll break down The Popkin Method’s sequential, practical approach to staying young, touching on gut health, muscle preservation, cognitive function, and the science behind advanced therapies. If you’re ready to understand anti-aging on a whole new level and get real, actionable strategies to improve your healthspan, tune in now!

Timestamps:
00:00 How NAD affects aging
04:17 Understanding mitochondria and energy production
07:32 Understanding nad depletion factors
10:41 Importance of muscle preservation
15:29 Importance of gut health
17:19 Gut health and diet impacts
21:49 Morning light and sleep patterns
24:33 Caloric cycling and fasting strategy
27:24 Balancing healthy living with treats
31:13 Understanding the epigenome and PARPs
33:23 The role of NAD in DNA repair
37:01 Different ways to boost NAD levels
40:15 Improving brain health naturally
44:20 Discussing plastics and hormone disruption
49:16 Stem cell and exosome therapies
51:25 Introducing the Popkin Method

You can see Dr. Popkin through his online virtual functional medicine program anywhere in the country or the world for that matter.
You can visit Dr. Popkin in his Hollywood Florida office for an in person weight loss experience.
Visit thepopkinmethod.com to send a message to schedule an appointment with Dr. Popkin or email Dr. Popkin at mcpopkinmd@yahoo.com.
Podcast Website - https://thepopkinmethod.com/
Matthew C. Popkin, M.D. - https://thepopkinmethod.com/about
Podcast Partner - TopHealth - https://tophealth.care/
“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”

Welcome back to The Popkin Method! In today’s episode, Dr. Matthew C. Popkin tackles one of the biggest challenges in modern healthcare: making care plans that truly stick. Most people don’t fail their health plans; the plans fail them, often because they’re too complex, reactive, or fragmented. Instead of bouncing between specialists and juggling conflicting advice, Dr. Matthew C. Popkin shares his approach for building a sustainable, integrated care strategy that focuses on foundational lifestyle changes and personalized medicine. Whether you’re dealing with chronic conditions, looking to optimize your performance, or simply tired of the revolving door of disconnected treatments, this episode is all about creating a clear, cohesive plan to help you achieve real, lasting results.

Timestamps:
00:00 Integrative and functional medicine approach
03:47 Challenges with wellness programs
08:26 Coordination challenges in healthcare
12:31 Integrating functional with traditional medicine
14:43 Patient reporting challenges and efficiency
18:45 The importance of health consistency
21:02 Importance of consistent exercise
24:06 Accountability in medical care
26:42 Managing expectations in weight loss
30:57 Evaluating Hormone and Cholesterol Health
35:15 Simplifying complex treatment plans
37:28 Introduction to the Popkin Method

You can see Dr. Popkin through his online virtual functional medicine program anywhere in the country or the world for that matter.
You can visit Dr. Popkin in his Hollywood Florida office for an in person weight loss experience.
Visit thepopkinmethod.com to send a message to schedule an appointment with Dr. Popkin or email Dr. Popkin at mcpopkinmd@yahoo.com.
Podcast Website - https://thepopkinmethod.com/
Matthew C. Popkin, M.D. - https://thepopkinmethod.com/about
Podcast Partner - TopHealth - https://tophealth.care/
“Disclaimer: Informational only. Not medical advice. Consult your doctor for guidance.”