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PodcastsHealth & WellnessMeSsy with Christina Applegate & Jamie Lynn Sigler

MeSsy with Christina Applegate & Jamie Lynn Sigler

Wishbone Production
MeSsy with Christina Applegate & Jamie Lynn Sigler
Latest episode

256 episodes

  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    We Fight For Joy with Kelsey Chittick

    2026-09-03 | 53 mins.
    This week on Living With It, Jamie sits down with Kelsey Chittick to talk about losing her husband suddenly, raising two children through grief, and learning to build a life she never expected. They discuss finding humor in the darkest moments, letting go of the life you thought you’d have, the power of community, and how to choose joy.

    Novartis in neuroscience

    o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    There’s No Place Like Home with Annie Meyers-Shyer

    2026-09-01 | 53 mins.
    This week, Jamie is joined by her longtime friend Annie Meyers-Shyer, the creator behind This Oak House. They talk about Annie’s unexpected second act, finding a new passion and career at 45, and why it’s never too late to bet on yourself. Annie also shares how she creates a home that feels like an exhale, the small ways our spaces can support us through difficult seasons, and how her home carried her through grief.

    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch

    This episode is sponsored by:

    Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

    Honeylove - Save 20% Off Honeylove by going to https://honeylove.com/messy #honeylovepod

    ZBiotics - Go to https://zbiotics.com/messy and use MESSY at checkout for 15% off any first time orders of ZBiotics probiotics.



    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    The Power of Radical Acceptance with Jim Curtis

    2026-08-27 | 53 mins.
    This week on Living With It, Jamie sits down with Jim Curtis, a transformational coach, author, and wellness leader. They discuss how to radically accept the life you have without giving up hope for the life you want, the stories we build around our suffering, and learning to see your body as an ally instead of the enemy. Plus, Jim shares how releasing old beliefs and changing the way we speak to ourselves can open us up to new possibilities.



    Novartis in neuroscience

    o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    Jamie's Son Beau

    2026-08-25 | 42 mins.
    This week, Jamie sits down with a very special guest: her 13-year-old son, Beau. They have an honest conversation about what it’s been like growing up with a mom who has MS, how Jamie’s strength has shaped him, and what he wants other kids and parents living with chronic illness to know.

    Executive Producers: Christina Applegate, Jamie Lynn Sigler, and Allison Bresnick

    Audio Engineer: Josh Windisch

    This episode is sponsored by: 

    Novartis in neuroscience - Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

    MudWtr -Start your new morning ritual & get up to 43% off your @MUDWTR with code MESSY at  https://mudwtr.com/messy! #mudwtrpod

    OneSkin - Get 15% off OneSkin with the code MESSY at https://www.oneskin.co/MESSY  #oneskinpod

    MyAlloy -Try the original estrogen-powered M4 skincare from Alloy. Visit myalloy.com and use code MESSYfor $20 off your first order!

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
  • MeSsy with Christina Applegate & Jamie Lynn Sigler

    Accept, Adapt, Appreciate with Odette Annable

    2026-08-20 | 54 mins.
    This week on Living With It, Jamie sits down with her friend Odette Annable. They discuss parenting a neurodivergent child, trusting your instincts, advocating for your family, and learning to let go of the need to have all the answers.

    Novartis in neuroscience

    o Our ambition is to create a transformational impact for people living with severe neurological conditions and their caregivers by discovering, developing and delivering innovative medicines that change the course of disease progression.

    Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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About MeSsy with Christina Applegate & Jamie Lynn Sigler
On this podcast, Christina Applegate and Jamie Lynn Sigler get vulnerable about the curveballs that life can throw…theirs just happens to be MS. Join them each week as they self-reflect, learn, laugh, and grow through their own raw and often-times hilarious conversations with each other, friends, co-stars, and the people that keep them going through the messiness of life.
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