The Dr. Gabrielle Lyon Show

Metabolic flexibility is your body’s ability to efficiently burn fat or carbohydrate depending on demand, may be one of the most important and least understood markers of long-term health. In this episode, I’m with Dr. Martin Gibala to explore the emerging science of Fat Max, why mitochondrial quality is central to both performance and longevity, and how sprint interval training produces comparable mitochondrial adaptations to traditional endurance work in a fraction of the time. Could the key to better metabolic health be less about the hours you log and more about how hard you’re willing to push?
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Email: [email protected]

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📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:
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Website: https://bit.ly/3NdV2kT
Books: https://bit.ly/4r6ugZK
Newsletter: https://bit.ly/402QCAj

⏰Timestamps:
00:00 Intro of Show
01:26 What is High-Intensity Interval Training?
05:04 HIIT to Improve Health Fundamentally
08:23 Exercise Ratio for General Individuals vs. Athletes
14:29 Dr. Lyon's Workout Routine
16:47 High-Intensity Interval vs. Sprint Interval Training
20:23 New Studies on Sprint Interval Training
24:57 The One-Minute Workout
26:57 CAROL Bike Mechanics
28:59 Benefits of High-Intensity Interval Training
37:21 Fuel Utilization: Sprint Interval vs. Slow, Steady-State Training
45:38 Metabolic Flexibility Definition
46:41 Fat Max Definition and Evaluation
50:26 Zone Training Model
58:00 Designing the Health of the Nation
1:04:04 How to Improve Body Composition
1:11:40 REHIT: Reduced Exertion, High-Intensity Training
1:21:59 Does HIIT Prevent Sarcopenia?
1:27:27 VO2 Max: Factoring Age and Sex
1:34:28 Designing the Ideal Workout Week
1:39:14 Importance of Rest Intervals
1:45:14 Connect with Martin

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
This episode includes paid sponsorships.

The most decorated woman in motorsports history will tell you she feared losing far more than she loved winning, and that fear is exactly what drove her to the top. In this episode, I’m with racing legend Danica Patrick to unpack the psychology of elite performance, from the “blind faith” that carried her through two decades of racing to the nervous system conditioning she built starting at age 10. What would be possible for you if you learned to channel pressure instead of escaping it?
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Listen to “Pretty Intense Podcast” on all your favorite platforms!
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Apple Podcasts: https://bit.ly/4s4I1cH

Get Danica Patrick’s book, “Pretty Intense” here: https://bit.ly/4rXdH3r

📱Connect with Danica Patrick
Website: https://bit.ly/4lfA9SQ
YouTube: https://bit.ly/3OVYeCk
Instagram: https://bit.ly/4bht0Ni
TikTok: https://bit.ly/4sCyDNf
Facebook: https://bit.ly/3Nuajhw
X.com: https://bit.ly/3Pdog3X
LinkedIn: https://bit.ly/4cWK6mn

🙌Thank you to our sponsors:
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📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:
YouTube: https://bit.ly/4boCFC3
Spotify: https://bit.ly/4cWTbLG

📱Connect with Dr. Gabrielle Lyon:
Instagram: https://bit.ly/4uk9adc
TikTok: https://bit.ly/3OFK3kJ
X.com: https://bit.ly/4l3YlaX
Facebook: https://bit.ly/3MBrJso
LinkedIn: https://bit.ly/3N1nrdL
Website: https://bit.ly/3NdV2kT
Books: https://bit.ly/4r6ugZK
Newsletter: https://bit.ly/402QCAj

⏰Timestamps:
00:00 Intro of Show
02:05 Understanding the Idea of Pressure and Challenge as a Kid
05:00 Managing Wins and Losses
09:45 Automaticity to Fear
11:44 Managing Nervous System under High Pressure
17:34 Danica's Pre-Performance Rituals
20:21 Performance Becoming One's Identity
21:23 Danica Working with Dr. Lyon
26:24 Discipline for Proper Recovery
28:47 Tips for Someone Going through the Same Issues
31:01 Working with Different Doctors
34:01 Women's Intuition in Hiring
37:14 Women in Male-Dominated Industries
41:42 There Are No Shortcuts to Success
43:01 Performing in High-Pressure Situations
45:51 Importance of Having Alone Time
48:34 What is Home Energy?
51:20 Flow of State: Passion and Creativity
55:51 Medicine in the AI Era
59:32 Rapid Fire Q&A

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.
This episode includes paid sponsorships.

I’m joined by Dr. Heather Hirsch to debunk the persistent myths surrounding hormone replacement therapy and explain why the 2002 Women’s Health Initiative data was so widely misinterpreted. We discuss how optimized estrogen, progesterone, and testosterone levels can protect your heart, bones, and brain health, helping you move past "normalized suffering" and into a proactive state of longevity. Whether you are in perimenopause or well past the ten-year window, you'll learn how to navigate personalized dosing and clinical data to reclaim your vitality and extend your health span.
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Get Dr. Heather Hirsch’s book, “The Perimenopause Survival Guide” here:
https://bit.ly/4r2yXUd
📱Connect with Dr. Heather Hirsch:
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LinkedIn: https://bit.ly/4u6rjeb
🙌Thank you to our sponsors:
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📺Watch the “Dr. Gabrielle Lyon Show” every Tuesday at 9AM EST:
YouTube: https://bit.ly/4boCFC3
Spotify: https://bit.ly/4cWTbLG
📱Connect with Dr. Gabrielle Lyon:
Instagram: https://bit.ly/4uk9adc
TikTok: https://bit.ly/3OFK3kJ
X.com: https://bit.ly/4l3YlaX
Facebook: https://bit.ly/3MBrJso
LinkedIn: https://bit.ly/3N1nrdL
Website: https://bit.ly/3NdV2kT
Books: https://bit.ly/4r6ugZK
Newsletter: https://bit.ly/402QCAj

⏰Timestamps:
0:00 Intro of Show
6:00 Hormone Replacement Therapy: Where Are We Now?
11:25 What is Menopausal Hormone Therapy?
13:39 How Safe is Hormone Replacement Therapy?
18:39 Access on the Studies on HRT
23:10 Risks of Hormone Replacement Therapy
27:24 Estrogen Does Not Cause Breast Cancer
31:19 Estrogen and Accelerated Bone Loss
34:51 Preventative Benefits of Estrogen
38:47 Lifespan vs. Health Span
39:22 When to Start Hormone Replacement Therapy?
45:15 Blood Markers
47:26 Progesterone: Effects, Timing, Dosage
52:38 Testosterone: Effects, FDA Approval, Benefits, Risks
1:00:44 Analysing the Numbers
1:04:13 Link of HRT and Cognitive Function
1:09:28 What Are Women Doing Wrong?

‼️Disclaimer: The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

This episode includes paid sponsorships.

Male fertility is declining, and most men have no idea why.
In this episode of The Dr. Gabrielle Lyon Show, Dr. Gabrielle Lyon sits down with Dr. Michael Eisenberg, Director of Male Reproductive Health at Stanford University and Chief Medical Advisor of SwimClub, to break down what truly determines sperm health and reproductive success.
They discuss:
How metformin, GLP-1 medications, testosterone therapy, and anabolic steroids affect male fertility
Why sperm count is a powerful biomarker for long-term health and longevity
The role of sleep, muscle mass, exercise, diet, marijuana, and environmental toxins like microplastics
Whether platelet-rich plasma, or PRP, can help severe male infertility
Daily habits that quietly reduce a couple’s chances of conceiving

If you care about fertility, hormones, metabolic health, or the future of men’s health, this conversation is essential.
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Find Dr. Michael Eisenberg at:
Eisenberg Lab: https://med.stanford.edu/eisenberglab.html
LinkedIn: https://www.linkedin.com/in/michael-eisenberg-9230a429
X: https://x.com/DrMEisenberg

Find Dr. Gabrielle Lyon at:
Instagram:@drgabriellelyon
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Order my new book - https://www.amazon.com/exec/obidos/ASIN/1668085623

Chapters:
00:00 Sex habits, libido, GLP-1s, and what counts as male infertility
01:46 Metformin and male fertility, what the Denmark study found
07:27 How long sperm take to regenerate after meds, illness, or chemo
09:24 GLP-1 medications, weight loss, and semen quality in men
10:52 Testosterone therapy, anabolic steroids, and why sperm shuts down
16:41 Sperm as a vital sign, fertility as a window into long term health
19:14 Microplastics and environmental toxins found in semen
22:21 Paternal age and sperm quality, DNA fragmentation and pregnancy risk
26:03 Supplements and nutrients for sperm quality, what matters and why
30:00 Sex frequency, masturbation, libido, and fertility myths
35:38 Male infertility guidelines and medications that quietly lower fertility
48:41 Semen quality and future disease risk, diabetes, cancer, mortality
54:45 Anabolic agents, sperm banking, and how long frozen sperm lasts
1:04:14 PRP for severe male infertility, azospermia and real outcomes
1:16:41 New frontiers in male fertility, immune profiles, genomics, omics

Disclaimers: This episode includes paid sponsorships.
The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.

Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.com
Self-doubt holds more people back than lack of skill or intelligence.
In this episode, Dr. Gabrielle Lyon sits down with Dr. Shadé Zahrai to explore the science of confidence, self-trust, and peak performance. They break down why confidence comes after action, how self-image shapes success, and the four psychological drivers that determine whether you thrive or stay stuck.
You will learn how body language influences perception, why high performers plan for failure, how perfectionism leads to burnout, and the subtle communication habits that undermine credibility. Most importantly, you will discover how to build what Dr. Zahrai calls Big Trust so you can back yourself before you feel ready.
If you struggle with overthinking, imposter thoughts, or feeling capable but not fully confident, this conversation will give you practical tools to change how you show up.
CHAPTERS
00:00 Confidence science: feeling vs appearing
00:51 The opposite of self-doubt and why confidence comes after action
01:53 Self-trust before confidence
03:03 Nonverbal confidence cues: posture, eye contact, smile, pace
07:30 Body language feedback loop: posture and recall
09:26 Shadé’s PhD on self-doubt under pressure
12:22 What makes people successful: self-image
12:30 Self-image blueprint and why change does not stick
14:29 The Four A’s: Acceptance, Agency, Autonomy, Adaptability
20:26 The self-awareness gap and changing personality traits
22:30 Expectation bias and the scar experiment
25:54 Self-doubt types: signal vs verdict
28:30 Visibility, influence, and the people around you
31:16 Which traits are easiest to change
35:56 Why capable people still stay stuck
40:25 Michael Phelps and visualizing failure recovery
42:30 Stop rumination: stimulus control for worry
47:45 Self-improvement vs perfectionism vs burnout
56:53 The 4 inner deceivers: Judge, Protector, Neglecter, Ringmaster
1:11:22 Peak performance and Big Trust
1:19:19 Communication habits that kill credibility
1:24:18 Stop over-apologizing and reframe emotion
1:29:47 Daily habits to build Big Trust and audit your circle
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Find Dr. Dr. Shadé Zahrai at:
IG: https://www.instagram.com/shadezahrai/
YouTube: https://www.youtube.com/shadezahrai
Big Trust by Dr. Shadé Zahrai gives you the tools to quiet self-doubt and step forward with clarity, agency, and confidence. Get your copy here: https://www.amazon.ca/Big-Trust-Self-Doubt-Confidence-Success/dp/0063378159

Find Dr. Gabrielle Lyon at:
Instagram: @drgabriellelyon
TikTok: @drgabriellelyon
Facebook: facebook.com/doctorgabriellelyon
YouTube: youtube.com/@DrGabrielleLyon
X (Twitter): x.com/drgabriellelyon
Apply to become a patient – https://drgabriellelyon.com/new-patient-inquiry/
Order my new book - https://www.amazon.com/exec/obidos/ASIN/1668085623

Disclaimers: This episode includes paid sponsorships.
The Dr. Gabrielle Lyon Podcast and YouTube are for general information purposes only and do not constitute the practice of medicine, nursing, or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast, YouTube, or materials linked from this podcast or YouTube is at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professional for any such conditions.