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This Week in Virology

Vincent Racaniello
This Week in Virology
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  • TWiV 1215: What's the worst that could happen?
    TWiV reviews universal vaccine initiative at NIAID, shut down of the Integrated Research Facility at Ft. Detrick, modeling the reemergence of infectious diseases as vaccination rates drop, and bacterial outer membrane vesicles bound to bacteriophages modulate neutrophil responses to bacterial infection. Hosts: Vincent Racaniello, Alan Dove, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Paul has Measles (YouTube, virology blog) Universal vaccine project (NIAID, CIDRAP) Measles update (US, Texas) Integrated Research Lab closed (Telegraph) Modeling reemergence of infectious diseases (JAMA) Outer membrane vesicles attached to phage (Front Cell Inf Micro) Pf phage review (Front Immunol) Letters read on TWiV 1215 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Alan – A Paradise Built in Hell, by Rebecca Solnit (and here’s my review of it) Jolene – Virology course student communication projects, Spring 2025 Vincent – Vaccine Education Center Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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  • TWiV 1214: Clinical update with Dr. Daniel Griffin
    In his weekly clinical update, Dr. Griffin with Vincent Racaniello bewail the attack on science within the US and withdrawal from the global health communities, association between the shingles vaccine and reduced dementia occurrence, ending of Uganda’s ebola outbreak, undermining effective responses to human bird flu infections, growing measles outbreak in the US and dire predictions of the return of vaccine preventable diseases including polio if vaccination rates continue to decline, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the WasterwaterScan dashboard, how HHS is undermining the Novavax COVID-19 vaccine, if Paxlovid reduces stroke, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Lab animal RIFFing (NY Times) Herpes zoster vaccination and dementia occurrence(JAMA) The recombinant shingles vaccine is associated with lower risk of dementia (Nature Medicine) Uganda declares end to latest ebola outbreak (Reuters) Enhancing the response to avian influenza in the US and globally (LANCET: Regional Health-Americas) H5 Bird Flu: Current Situation (CDC: Avian Influenza Bird flu) Measles Update — United States, January 1–April 17, 2025 (CDC: MMWR) Measles in Europe……..but greater in the US (CIDRAP) Measles – Annual Epidemiological Report for 2024 (ECDC: European Center for Disease Prevention and Control) Measles (ECDC: European Center for Disease Prevention and Control) Measles cases and outbreaks (CDC Rubeola) Measles 800 in Texas…. (Texas Health and Human Services) 2025 Measles outbreak guidance (New Mexico Health) On the precipice of disaster’: Measles may be endemic in 25 years if vaccine uptake stays low, model predicts (CIDRAP) Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US (JAMA) Measles vaccine recommendations from NYP (jpg)  Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola)) Measles (CDC: Measles Rubeola) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) Respiratory virus activity levels (CDC Respiratory Illnesses) 200 children die from flu (CIDRAP) Weekly surveillance report: clift notes (CDC FluView) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) RSV: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Health secretary RFK Jr. declares certain vaccines have ‘never worked,’ flummoxing scientists…..what certain vaccines?(STAT News) More FDA uncertainty roils full approval for Novavax COVID vaccine (CIDRAP) FDA Punts on Major Covid-19 Vaccine Decision After Ouster of Top Official (WSJ) U.S. health officials inject new uncertainty into approval process for Covid boosters (STAT News) Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Into the Unknown: Practical Remdesivir Restriction in the Era of Widespread SARS-CoV-2 Seropositivity (CID) Tocilizumab and IVIG experience during the service follow-up in patients with severe COVID-19 pneumonia(Rev Insti MedTrop Sao Paulo) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection(JAMA) Reaching out to US house representative Letters read on TWiV 1214 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.
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  • TWiV Special: A shot of HepB with Chari Cohen
    From the 2024 International Hepatitis B virus meeting in Chicago IL, Rich Condit speaks with Chari Cohen about her work as President of the Hepatitis B Foundation. Host: Rich Condit Guest: Chari Cohen Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Hepatitis B Foundation Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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  • TWiV 1213: Secrets of HepB cccDNA
    TWiV reviews new committee of experts to counter vaccine misinformation, resignation of NSF Director, dependence of immune response to rabies virus on the gut microbiome, and a nucleosome switch primes hepatitis B virus infection. Hosts: Vincent Racaniello, Rich Condit, and Angela Mingarelli Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV ASV 2025 Committee of experts to counter vaccine misinformation (Science) NSF Director resigns (Science) Dependence of vaccine immune response on gut microbiome (Cell Host Microbe) Nucleosome switch primes HepB replication (Cell) Letters read on TWiV 1212 Timestamps by Jolene Ramsey. Thanks! Weekly Picks Angela – Wild chimpanzees filmed by scientists bonding over alcoholic fruit Rich – Malcolm Gladwell Revisionist History “The Joe Rogan Intervention” Vincent – Measles Misinformation Is on the Rise — and Americans Are Hearing It, Survey Finds Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.
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  • TWiV 1212: Clinical update with Dr. Daniel Griffin
    In his weekly clinical update, Dr. Griffin with Vincent Racaniello deplore the US’s withdrawal from the global health community for pandemic preparedness i.e. the universal avian flu vaccine, and undermining the use of routine childhood vaccinations for pertussis and measles, RFK’s autism registry, yellow fever outbreak in Colombia and world immunization week after discussing the squirrel as the reservoir host for mpox, before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the WasterwaterScan dashboard, how immunity elicited by the RSV vaccine wanes in 3 years, if Paxlovid reduces stroke, where to find PEMGARDA, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, if vaccination impacts long COVID and if long COVID were to become epidemic. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode The American Public’s Disengagement With Highly Pathogenic Avian Influenza (HPAI): Considerations for Vaccination and Dietary Changes(American Public Health Association) New agreement geared toward universal avian flu vaccine (CIDRAP) Cambridge’s DIOSynVax and Singapore’s ACM Biolabs to advance pandemic-ready universal bird flu vaccine with international support (GlobeNewswire) Bird flu continues to spread among live poultry markets after shut down order  (CRAIN’S New York Business) Fire-footed rope squirrels (Funisciurus pyrropus) are a reservoir host of monkeypox virus (Orthopoxvirus monkeypox)(Research Square) It is a squirrel! An animal source of mpox emerges(Nature) Whooping cough spikes, especially among unvaccinated teens (NBC News) A February flu surge has arrived (NCB News) Pertussis Cases by Year (1922-2022)(CDC: Whooping cough (pertussis))) ‘Fighting to breathe’: Whooping cough surges as vaccination rate falters (NBC News) CDC cancels measles help for Texas schools amid staff layoffs (HealthDay) Measles cases and outbreaks (CDC Rubeola) Measles in Texas…. (Texas Health and Human Services) Measles vaccine recommendations from NYP (jpg)  2025 Measles outbreak guidance (New Mexico Health) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola)) Measles (CDC: Measles Rubeola) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) RFK Jr.’s autism registry plan (Axios) RFK Jr’s autism study collecting Americans’ private medical records (Guardian) The public’s views on measles outbreaks and misinformation (KFF)  Colombia National Emergency: yellow fever cases (Gov.Co) World Immunization Week: polio eradiation?(GPEI) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Weekly surveillance report: clift notes (CDC FluView) Respiratory virus activity levels (CDC Respiratory Illnesses) 200 children die from flu (CIDRAP) Weekly surveillance report: clift notes (CDC FluView) FDA-CDC-DOD: 2025-2046 influenza vaccine composition (FDA) RSV: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Trial shows waning efficacy of RSV vaccine across 3 seasons in older adults(CIDRAP) Efficacy, safety, and immunogenicity of the AS01E-adjuvanted respiratory syncytial virus prefusion F protein vaccine (RSVPreF3 OA) (LANCET: Respiratory Medicine) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Long-term stroke and mortality risk reduction associated with acute-phase paxlovid use in mild-to-moderate COVID-19(Journal of Medical Virology) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID The effect of COVID-19 vaccination on the risk of persistent post–COVID-19 condition (JID) ORCHESTRA Delphi consensus: diagnostic and therapeutic management of Post-COVID-19 condition in vulnerable populations (CMI Clinical Microbiology and Infection) Political ideology and trust in scientists in the USA(Nature Human Behavior) Leading long COVID researcher fears it could become a national epidemic (Spectrum News NY1) Center for post COVID care (Mt. Sinai) Reaching out to US house representative Letters read on TWiV 1212 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.
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