Solve for X: Innovations to Change the World

• Cracking the code: How generative biology could transform medicine

  Can AI unravel the mysteries of human biology? Could it help design specialty treatments and cures for disease? Geoffrey von Maltzahn and his team at Generate:Biomedicines are bullish on both counts. AI has greatly accelerated progress in genome engineering, bioengineering and nanotechnology and they are getting closer to developing tailored therapeutics. “Six years ago, this was a crazy idea,” he says. “We’re now convinced that 100 percent of protein therapeutics are going to get created this way.” In this special episode of Solve for X, host Manula Selvarajah sits down with von Maltzahn to talk about where the science is now and where it is headed.  Featured in this episode: Geoffrey von Maltzahn, general partner of  Flagship Pioneering, is an inventor and entrepreneur who works at the intersection of biology and artificial intelligence, a specialization that makes him a world-renowned leader in generative biology.  Further reading: How generative biology can wipe out our most devastating diseases — for goodHow technology is tackling questions that confound modern medicineHow we can deliver a better tomorrow through generative biologyThe frontiers of generative biology | MaRS Impact Health 2024Subscribe to Solve for X: Innovations to Change the World here. And below, find a transcript to “Cracking the code: How generative biology could transform medicine.” This interview was recorded at MaRS Impact Health in June 2024. Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.

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• Innovation hotline: Answering the tech sector’s burning questions

  Featured in this episode: Alison Nankivell has spent more than 25 years moving Canada’s economic needle forward. Before being named CEO of MaRS in early 2024, Alison held pivotal roles at the Business Development Bank of Canada (BDC), the Ontario Teachers’ Pension Plan and Export Development Canada (EDC). At MaRS, she brings an experienced playbook to support startups working in climate, health and emerging technology. Kris Bennatti is the CEO and co-founder of Hudson Labs, a Toronto-based startup that builds specialized financial software to help improve corporate accountability in capital markets. Lise Birikundavyi is the co-founder and managing partner of BKR Capital, Canada’s first Black-led, institutionally-backed VC fund. Birikundavyi is a finance specialist who has worked with several international institutions, including the Jacobs Foundation where she managed its edtech impact investment strategy.  Corey Ellis is the co-founder and CEO of Growcer. The Ottawa-based startup develops commercial hydroponic systems that help communities grow indoor produce, year-round in any climate.   Charles Plant is a serial entrepreneur, innovation economist, fractional CFO and founder of The Narwhal Project, which helps tech startups raise capital and scale business.  Further reading: Welcome to the $100-million clubUndervalued and ignored: Why young Canadian firms are looking to foreign investors and buyers Evolving ESG reporting regulations call for co-ordinated executive action in CanadaDEI in Canadian workplaces is hitting a wall, subscriber survey showsNorth American outlook: Uncertain political environment adds to business, consumer fatigueClimate adaptation is as important as climate mitigationSubscribe to Solve for X: Innovations to Change the World here. And below, find a transcript to “Innovation hotline: Answering the tech sector’s burning questions.” This interview was recorded October 17 in the MaRS Studio.  Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.

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• Soak it up: Can sponge cities save us from flooding?

  Featured in this episode: Kongjian Yu is a Beijing-based landscape architect and founder of Peking University’s College of Architecture and Landscape. His concept of sponge cities — designing cities to absorb water — is being applied in urban areas across the globe.  Further reading:Landscape architect Kongjian Yu, pioneer of the “sponge city" concept, wins the 2023 Oberlander PrizeHow letting water be water can lead to better climate resilienceKongjian Yu has a plan for urban flooding: “Sponge cities”Treading water — Toronto is spending billions on flood protection, but experts say it needs to spend billions moreWill a $1-billion flooding bill finally make the GTA take stormwater seriously?Toronto’s Don River floods offer urgent planning lessons for climate-challenged cities Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.

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• Striking a chord: Why neuroscientists believe music could hold the power to cure what ails us

  Music makes us feel better — for most of us, this is an intuitive truth. But scientists are only now beginning to understand the remarkable ways that music affects our brains. With the help of innovation, researchers are working to assess and codify the whats, whys and hows that could help us harness this power as a therapeutic tool to treat people grappling with everything from mood disorders to Parkinson’s disease. Their data is helping prove that music could be one of our most vital, valuable and accessible forms of medicine. Featured in this episode:Dan Levitin is a best-selling author, music producer, renowned neuroscientist and professor emeritus in psychology at McGill University. His latest book, I Heard There Was a Secret Chord: Music as Medicine was released in August. Frank Russo is a cognitive neuroscientist and psychologist who serves as the chief science officer at LUCID, a Toronto-based company that uses AI to create personalized music therapy to help people with mental health challenges. He’s also a professor of psychology at Toronto Metropolitan University, where he heads up the Science of Music Auditory Research and Technology (SMART) lab. Jessica Grahn is a neuroscientist and a professor at Western University. She studies how the brain processes music and its power to activate music in people with mobility issues brought on by neurodegenerative diseases like Parkinson’s. Charlotte Cumberbirch is a professional choral singer who leads an online vocal health group for older adults at the Cummings Centre in Montreal. Many of her participants are recovering from strokes or dealing with brain diseases, such as Parkinson’s. Further reading:The sound of science: How music can transform our brainsAI to benefit humanity: Innovations in senior careThe big idea: could we use music like medicine?AI is unlocking the human brain’s secretsHow does music affect your brain? This is your brain. This is your brain on music Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com.

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• Solve for X S3 Trailer

  In season 3 of Solve for X, we meet the innovators and entrepreneurs solving for climate change, economic disparity, diseases and more. Subscribe and listen beginning September 26.Solve for X is brought to you by MaRS, North America’s largest urban innovation hub and a registered charity. MaRS supports startups and accelerates the adoption of high-impact solutions to some of the world’s biggest challenges. For more information, visit marsdd.com. 

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