The Primal Podcast

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Is your "healthy" diet the hidden cause of your anxiety, fatigue, or depression? In this groundbreaking episode, Dr. Georgia Ede (MD), a Harvard-trained psychiatrist with over 25 years of clinical experience, joins us to break down the "chemical imbalance" theory of mental health. Dr. Ede explains the role of metabolic dysfunction in the brain.
Referencing the 2026 expert-informed clinical guidance for Ketogenic Metabolic Therapy (KMT), Dr. Ede explains how glucose hypometabolism, a state where the brain can no longer effectively process sugar, leads to neuroinflammation and psychiatric symptoms. From the pathophysiology of "brain insulin resistance" to the role of cholesterol in synaptic health, this conversation provides the clarity needed to heal the mind from the root cause. Whether you are battling treatment-resistant depression or seeking to optimize cognitive longevity, this episode bridges the gap between high-level clinical research and practical human experience.

This episode is brought to you by the⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠Primal Tallow Soaps & Balms.⁠⁠⁠⁠
Is there a single "metabolic switch" that can accelerate weight loss while repairing your cells? In this episode, world-renowned metabolic researcher Dr. Dom D’Agostino (PhD) joins us to explain the science of autophagy, ketosis, and the gut microbiome. Referencing decades of laboratory research and clinical observation, Dr. D’Agostino explains why the traditional "calories in, calories out" model fails to account for cellular signaling and nutrient density.
From the specific biochemical benefits of "sardine fasting" to the role of ketones in preserving gut barrier integrity, this conversation provides the medical clarity needed to optimize your biology. Whether you are looking to reverse metabolic dysfunction or seeking the latest data on nutritional ketosis, this episode bridges the gap between science and practical human experience.

This episode is brought to you by Primal Tallow Balms & Soaps.

Is it possible that "clogged arteries" and high cholesterol aren't the primary causes of heart attacks? In this episode, Dr. Tom Cowan (MD) joins us to challenge the 80-year-old Thrombogenic Theory and break down the clinical reality of cardiovascular health. Drawing from his experience overseeing more than 100,000 patient cases, Dr. Cowan explains why traditional cardiology’s focus on LDL and plaque often misses the true physiological triggers of heart disease. From the power of collateral circulation to the impact of metabolic acidosis on heart tissue, this episode provides the medical clarity needed to look past the "clogged pipe" model and understand how the heart actually functions. Whether you are tracking your own markers or are a healthcare professional seeking root-cause insights, this conversation bridges the gap between historical medical literature and modern clinical reality.

The most effective weight-loss method that never fails, with Dr. Eric Westman. If you want to lose weight and fix a disease, eat these foods. Is it possible to lose weight without counting a single calorie or tracking every gram of fiber?
In this episode, Dr. Eric Westman (Associate Professor of Medicine at Duke University) joins us to break down the clinical reality of weight loss, the power of low-carb living, and the emerging science of Euketonemia. From his decades of clinical experience, Dr. Westman explains why the traditional "eat less, move more" model fails and how targeting insulin, not just calories, is the key to unlocking stubborn fat stores. Whether you're a keto veteran or just starting your journey, this episode provides the medical clarity needed to simplify your diet and see results.

Is your "unexplained" fatigue actually mitochondrial failure? Today, we are joined by the world-renowned Dr. Sarah Myhill, a pioneer in treating Chronic Fatigue Syndrome (ME/CFS) and author of Diagnosis and Treatment of Chronic Fatigue Syndrome. If you’ve been told your blood tests are "normal" but you still feel exhausted, this episode reveals the root causes that conventional medicine often overlooks—from mitochondrial dysfunction and thyroid regulation to the hidden toxins in our food and water.

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In This Episode, We Reveal:
The Mitochondria Connection: Why these cellular powerhouses are the key to reversing chronic fatigue.
The Caffeine Trap: How your morning coffee might be draining your adrenal reserves.
The Fermenting Gut: Why bloating and brain fog are signs of upper gut bacterial overgrowth.
Environmental Detox: The truth about glyphosate, fluoride, and heavy metals in your daily life.
The Paleo-Ketogenic Solution: Why Dr. Myhill advocates for a high-fat, low-carb approach to fuel the heart and brain.