Aging Powerfully with Melissa Grelo

Academy Award–winning actress Marcia Gay Harden joins me on Aging Powerfully with Melissa Grelo for an intimate conversation about losing her mother to Alzheimer’s — and what it taught her about love, grief, and what truly endures.

In honour of Alzheimer’s Awareness Month, Marcia shares the heartbreaking and beautiful moments of walking beside her mother as memory fades, along with what she’s learned about women’s brain health, risk, and prevention — and the changes she has made in her own life since her mother’s battle with the disease.

I was fortunate to sit down with Marcia in Toronto at the first-ever Women’s Brain Health Summit, where she spoke powerfully about her personal journey and the urgent need for more research, funding, and awareness around a disease that disproportionately impacts women.

This is a conversation about more than illness — it’s about what remains when memory disappears, and how love never does.

Tech and Audio Producer: Drew Garner 

Producer: Melissa Grelo (@MelissaGrelo, @AgingPowerfullyWithMelissaGrelo)

For any partnership inquires, contact [email protected]

January is Alzheimer’s Awareness Month in Canada, and this episode tackles a critical — and often overlooked — reality: nearly two-thirds of Alzheimer’s diagnoses are in women.

Melissa is joined by returning guest Dr. Liisa Galea (previous Episode #46), a world-renowned neuroscientist, inaugural womenmind Treliving Family Chair in Women’s Mental Health, Senior Scientist, Centre for Addiction and Mental Health (CAMH), and Professor of Psychiatry, University of Toronto, where she helps guide evidence-based research and innovation focused on brain health and aging.

Dr. Galea shares the latest science on women’s brain health, the menopausal brain, and why decades of male-focused research have left dangerous gaps in our understanding of Alzheimer’s risk in women. Together, they explore what we know, what we’re still learning, and where research must go next to close the gender gap in neuroscience.

In this episode, we discuss:
Why women account for the majority of Alzheimer’s cases
How menopause and hormonal changes affect the brain
The role of inflammation, stress, and aging in cognitive health
Emerging research in dementia prevention
What women can do now to support brain health — without fear

This is an empowering, evidence-based conversation about awareness, advocacy, and protecting women’s brains across the lifespan.

Tech and Audio Producer: Drew Garner 

Producer: Melissa Grelo

For any partnership inquires, contact [email protected]

2025 was one of my busiest—and most meaningful—years yet. Thank you for being on this journey with me and for showing up week after week to learn, question, laugh, and age powerfully together.

As we wrap up the year, this episode is a Power Replay: a look back at the incredible conversations from Season 3, plus a preview of what’s coming in 2026.

Note: We’ll be taking a short break, with new episodes returning in January 2026—so now is the perfect time to catch up on anything you missed.
Looking Ahead to 2026
So much is coming next year, including deep dives into:

PCOS
Endometriosis
Fibroids
Pregnancy during perimenopause
Breast cancer
Cancer screenings in midlife
Evidence-based strategies for better sleep
Caregiving in Canada (over 13 million unpaid caregivers)
A very special episode featuring my parents, my most beloved role models
Stay Connected
I want to hear from you.

What topics do you want us to tackle next?

Reach me via my website: agingpowerfullywithmelissagrelo.com

Or connect on Instagram: @melissagrelo, @agingpowerfullywithmelissagrelo

Wishing you peace, good health, prosperity, and clarity in 2026.

Merry Christmas

Happy Hanukkah

Happy Holidays

Tech and Audio Producer: Drew Garner 

Producer: Melissa Grelo

For any partnership inquires, contact [email protected]

In this episode of Aging Powerfully, Melissa digs into one of the most emotional (and common!) midlife topics: hair loss, with medical and cosmetic dermatologist, Dr. Renée A. Beach (@dermabeach). From thinning at the crown to shedding in the shower, we talk about why it happens, what’s normal, and when to investigate further.

We cover:

How perimenopause, menopause, stress, and genetics impact hair
The difference between “normal shedding” and true hair loss
Medical causes to rule out (like thyroid issues, iron levels, and hormones)
Evidence-based treatments vs. overhyped “miracle” cures
Practical strategies to protect hair health from the inside out
The emotional toll of hair loss and how to protect your confidence and identity

If you’ve ever felt panicked by the hair in your brush or avoided looking at your part in photos, this episode will give you clarity, options, and a lot of compassion.

Tech and Audio Producer: Drew Garner 

Producer: Melissa Grelo (@melissagrelo, @agingpowerfullywithmelissagrelo)

For any partnership inquires, contact [email protected]

(Originally aired May 23, 2024)

In this uplifting episode, Melissa sits down with mother-daughter powerhouse Joan MacDonald (@trainwithjoan) and Michelle MacDonald (@michellemacdonaldofficial) to explore what’s truly possible when women choose strength, consistency, and self-belief — no matter their age.

Joan began her fitness journey at 70 and has since inspired millions of women to reclaim their health. Michelle, her coach and daughter, shares the training, nutrition, and mindset strategies that made Joan’s transformation sustainable and life-changing.
What We Cover:
Joan’s turning point and how she began at age 70
Michelle’s expert approach to strength training for women in midlife
The emotional and identity shifts that come with reinventing yourself
Why it’s never too late to build strength, confidence, and vitality
How visibility and community empower women to age powerfully

Tech and Audio Producer: Drew Garner 

Producer: Melissa Grelo (@melissagrelo, @agingpowerfullywithmelissagrelo)

For any partnership inquires, contact [email protected]