Behind the Breakthroughs podcast | Listen online for free

46 episodes

Amit Etkin: Precision Psychiatry’s Future Isn’t Genomics—It’s Brain Activity
2026-07-15 | 1h
For decades, psychiatry has relied on symptom-based diagnosis and trial-and-error treatment, but precision medicine is set to transform mental health care by using objective biological measures—such as EEG, sleep and circadian rhythm data, and cognitive testing—with AI-driven analysis to match patients with the therapies most likely to work for them. In this episode of Behind the Breakthroughs, Alto Neuroscience founder and CEO Amit Etkin explains how biomarker-guided drug development and biologically defined patient populations could make precision psychiatry routine, improving outcomes and changing how psychiatric disorders are diagnosed and treated.

Produced and hosted by Jonathan D. Grinstein, PhD
Audio mixed and mastered by Erick Ziegler
Brought to you by Inside Precision Medicine (SAGE Publishing)
Hosted on Acast. See acast.com/privacy for more information.
Michael Antonov: From Virtual World Builder to Real-World Drug Designer
2026-07-01 | 1h 2 mins.
AI is transforming biomedical research, but meaningful advances in drug discovery require more than just increasingly powerful algorithms—they depend on combining machine learning with physics-based simulations, mechanistic models, and rigorous experimental validation. In this episode of Behind the Breakthroughs, Michael Antonov, co-founder of Oculus and computational drug discovery company Deep Origin, shares a pragmatic perspective on AI's opportunities and limitations in medicine, explaining where it is accelerating innovation and why human expertise and experimental science remain indispensable.

Produced and hosted by Jonathan D. Grinstein, PhD
Audio mixed and mastered by Erick Ziegler
Brought to you by Inside Precision Medicine (SAGE Publishing)
Hosted on Acast. See acast.com/privacy for more information.
Philippe Pouletty: Turning Europe’s Life Science Startups Into World Leaders
2026-06-17 | 58 mins.
Philippe Pouletty, MD, is one of Europe’s most successful life sciences entrepreneurs, having spent more than 30 years building category-leading biotechnology and medical technology companies from breakthrough scientific innovations. His most notable achievement is Abivax, which he founded and chaired for a decade, transforming it into a global biotechnology leader that reached an approximately $10 billion market capitalization following positive Phase 3 results in 2025. Today, he is applying the same proven strategy to Carvolix, combining breakthrough implants, AI-powered software, and autonomous mini-robotics to create a next-generation cardiovascular MedTech company focused on improving outcomes for patients with heart valve disease and stroke.

Produced and hosted by Jonathan D. Grinstein, PhD
Audio mixed and mastered by Erick Ziegler
Brought to you by Inside Precision Medicine (SAGE Publishing)
Hosted on Acast. See acast.com/privacy for more information.
Arthur Caplan: The Right to Life, Liberty, and Pursuit of Health
2026-06-03 | 1h
While growing up during the polio era, Arthur Caplan, PhD, saw doctors hide painful truths from families and children, which sparked his lifelong questions about power, protection, and inequality in medicine. In this episode, Caplan claims that bioethics has changed from marginalizing or abandoning disabled people to genetic testing, parental perfectionism, and personal autonomy over collective responsibility. Caplan predicts that extreme individualism will endanger public health and that the next ethical frontier will be the brain and how far humans should alter identity.

Produced and hosted by Jonathan D. Grinstein, PhD
Audio mixed and mastered by Erick Ziegler
Brought to you by Inside Precision Medicine (SAGE Publishing)
Hosted on Acast. See acast.com/privacy for more information.
Carolina Aguilar: Brain-Computer Interfaces that Heal Neural Circuits
2026-05-20 | 54 mins.
Brain-computer interfaces have gained widespread attention largely for assistive applications, but Carolina Aguilar sees their greatest potential in directly treating neurological disease. Through INBRAIN Neuroelectronics, she is developing graphene-based implants designed to read and stimulate neural activity with far greater precision than conventional devices, building on insights from her 13 years at Medtronic and earlier neuroscience research. In this conversation, Aguilar explains why INBRAIN prioritizes therapeutic BCIs, how graphene could advance personalized neurotechnology and AI-driven therapies, and why conditions such as Parkinson’s disease, epilepsy, and cardiometabolic disorders are central to the company’s long-term vision.

Produced and hosted by Jonathan D. Grinstein, PhD
Audio mixed and mastered by Erick Ziegler
Brought to you by Inside Precision Medicine (SAGE Publishing)
Hosted on Acast. See acast.com/privacy for more information.

More Health & Wellness podcasts

Trending Health & Wellness podcasts

About Behind the Breakthroughs

Join host Jonathan D. Grinstein, PhD, North American Editor for Inside Precision Medicine, as he uncovers the stories behind the pioneers driving the precision medicine revolution. Behind the Breakthroughs features candid interviews with seasoned veterans and rising stars, exploring their origin stories and groundbreaking contributions advancing the frontiers of patient diagnosis, treatment, and care.In every episode, Jonathan goes beyond the science, diving deep into the personal and professional journeys of those striving to make these incredible new therapies more equitable and accessible globally. You'll discover how emerging technologies in molecular diagnostics, next-generation sequencing, genetic medicines (e.g., cell and gene therapies), and AI/ML are transforming treatment and bringing precision medicine closer to the forefront of healthcare. Whether you’re a researcher at a large pharma company or small biotech startup, a clinician at a major health system or community setting, a laboratory technician in the clinic or academia, an investor at a premier or venture capital firm, or just interested in the latest in medicine and healthcare, these interviews will inspire and inform you about personalized medicine's future. Hosted on Acast. See acast.com/privacy for more information.

Podcast website

Health & Wellness Medicine Science Technology

Listen to Behind the Breakthroughs, Sexe Oral and many other podcasts from around the world with the radio.net app

Get the free radio.net app

Stations and podcasts to bookmark
Stream via Wi-Fi or Bluetooth
Supports Carplay & Android Auto
Many other app features

Open app

Get the free radio.net app

Stations and podcasts to bookmark
Stream via Wi-Fi or Bluetooth
Supports Carplay & Android Auto
Many other app features

Behind the Breakthroughs

Scan code,
download the app,
start listening.