High on Life

• Retatrutide - Top-Line Results from TRIUMPH 4

  In this quick update, I break down the newest Phase 3 data for retatrutide, Lilly’s investigational triple-agonist medication showing unprecedented results in obesity and knee osteoarthritis. Highlights: Up to 28.7% weight loss (~71 lbs) over 68 weeks 75% reduction in knee pain and major improvements in physical function Cardiometabolic benefits: lower triglycerides, non-HDL cholesterol, hsCRP, and blood pressure We also cover Common side effects and safety signals Perceived excessive weight loss — and what this means for clinical practice in a new era of powerful medications A reality check on Canadian availability (likely 3+ years away) A strong warning about illegal online sales and the risks of buying unregulated products A concise medical breakdown to help you stay informed and safe as the obesity-medicine landscape evolves.

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• 161. The Overlap between Binge Eating Disorder and Obesity (Part 2)

  161. The Overlap between Binge Eating Disorder and Obesity (Part 2) In this episode, I’m breaking down the difference between Binge Eating Disorder (BED) and the emotional or hedonic eating patterns we often see in obesity. While BED and obesity can overlap, they’re not the same — and treatment looks very different for each. I share who to screen for BED, how to ask about eating behaviours with compassion, and the most effective treatment options, including CBT-ED, nutrition therapy, and medications. Then I shift into understanding non-BED overeating patterns driven by emotional eating, all-or-nothing thinking, and over-desire around food. If you want a clearer, more compassionate understanding of eating disorders and obesity-related eating behaviours, this episode will guide you through both. WORK WITH ME Recover Strong CBT-ED program for Binge Eatinghttps://www.sashahighmd.com/bed O​​ntario-Wide Virtual Obesity Management Clinichttps://www.highmetabolicclinic.com Join my Lifestyle Coaching Program for women, Best Weighthttps://www.sashahighmd.com/bestweight Taking the first step toward weight loss can feel overwhelming — but you don’t have to do it alone. I’ve created a curated list of my podcast episodes to gently guide you as you begin your journey. https://www.sashahighmd.com/podcast-guide

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• 160. Eating Disorders vs. Obesity-Related Eating Behaviours (Part 1)

  160. Eating Disorders vs. Obesity-Related Eating Behaviours (Part 1) In today’s episode, I walk through the spectrum of disordered eating — from everyday overeating to clinically significant eating disorders like binge eating disorder and bulimia nervosa. I explain how these behaviours differ, where they overlap, and why so many people feel confused about their relationship with food. I also cover the science behind appetite, reward pathways, and why some individuals are more vulnerable than others. This episode will help you understand the foundations before we dig deeper next week! WORK WITH ME The Menopause Solution Coursehttps://www.sashahighmd.com/the-menopause-solution Health Coaching Program for women, Best Weighthttps://www.sashahighmd.com/bestweight Recover Strong for Binge Eatinghttps://www.sashahighmd.com/bed Ontario-Wide Virtual Obesity Management Clinichttps://www.highmetabolicclinic.com

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• 159. Nutrition in the Menopause Transition

  159. Nutrition in the Menopause Transition In this episode of High on Life, we dive into one of the most common and confusing challenges women face during the Menopause transition: understanding how to nourish their changing bodies. Registered dietitian and Best Weight coach, Tedi Nikova, RD, MPH, breaks down what’s really happening with hormones like estrogen, testosterone, and insulin—and how these shifts impact hunger, metabolism, and fat distribution. You’ll learn clear, sustainable strategies for regulating blood sugar, building muscle, and creating balanced meals without cutting out major food groups or falling for social media myths. From practical protein goals to simple meal structure tips and mindset shifts, this episode gives you the tools to work with your body, not against it. Plus, get a sneak peek of the upcoming Menopause Course with Dr. Sasha High, designed to help women feel strong, informed, and empowered through midlife and beyond. The Menopause course is now live:https://www.sashahighmd.com/offers/QpxVQo7n/checkout FOLLOW US: Instagramhttps://www.instagram.com/sashahighmd/ WORK WITH US: Join my Weight Loss Coaching Program for women, Best Weight https://www.sashahighmd.com/bestweight Recover Strong for Binge Eatinghttps://www.sashahighmd.com/bed Ontario-Wide Virtual Obesity Management Clinichttps://www.highmetabolicclinic.com Feeling ready to start your weight loss journey—but not sure where to begin? You don’t have to do it alone. I’ve created a curated list of my podcast episodes exclusively for my podcast listeners. This list is designed to gently guide you through those first steps toward lasting change. Download your free podcast list and let’s take that first step together!

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• 158. How to Build Resilience When You Want to Quit

  Episode 158 — How to Build Resilience When You Want to Quit In this episode, I’m talking about what to do when you hit that wall — when motivation fades, things feel hard, and you just want to give up. Resilience isn’t about being tough or forcing your way through. It’s about how quickly you can recover, adapt, and get back into action when life throws challenges your way. I share the psychology and neuroscience behind resilience — what’s happening in your brain when you want to quit, and how to train your thinking so you don’t get derailed by stress or frustration. You’ll learn how the prefrontal cortex and amygdala work together when you’re under pressure, why tolerating discomfort builds emotional endurance, and how small mindset shifts can literally rewire your brain for grit and perseverance. I also walk through practical, science-based tools you can start using right away: reframing stress as energy, practicing “micro-recoveries” throughout the day, using controlled doses of challenge to strengthen your nervous system, and labeling emotions to calm your brain before taking action. Resilience isn’t a personality trait — it’s a skill. And every time you show up when it’s hard, you’re training that skill. If you’ve been tempted to quit lately, this episode will help you understand what’s really happening beneath the surface — and how to keep going, without burning out or beating yourself up. Feeling ready to start your weight loss journey—but not sure where to begin? You don’t have to do it alone. I’ve created a curated list of my podcast episodes exclusively for my podcast listeners. This list is designed to gently guide you through those first steps toward lasting change.Download your free podcast list and let’s take that first step together!

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