This Week in Cardiology

Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets after cardiac arrest are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
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Oct 10, 2025 This Week in Cardiology Podcast
https://www.medscape.com/viewarticle/1002990
ICE vs TEE in Atrial Fibrillation Ablation https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370
II FFR Without the Wire – Angiography-Derived FFR to Guide PCI
ALL-RISE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600949
FAST III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601841
FAVOR III Trial 10.1016/S0140-6736(24)02175-5 External Link
FAME 2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1205361
 
Venk Murthy on X https://x.com/venkmurthy/status/2074849421452329456?s=20
III More Bad News for Ticagrelor
Jul 11, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1002704
Prasugel, Ticagrelor, or Clopidogrel After PCI https://jamanetwork.com/journals/jamacardiology/fullarticle/2849614
IV The Polypill in Heart Failure
POLY-HF trial https://www.nature.com/articles/s41591-026-04504-5
V Oxygen Targets After Cardiac Arrest
LOGICAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513814
ICU-ROX Trial https://link.springer.com/article/10.1007/s00134-020-06196-y
Secondary Analysis of the PILOT Trial https://journal.chestnet.org/article/S0012-3692(25)00553-7/fulltext
Oxygen Targets in Comatose Survivors of Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa2208686
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Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
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PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137
II Statins and Frailty
Statin Initiation Tied to Lower Frailty Risk in Older Adults https://www.medscape.com/viewarticle/statin-initiation-tied-lower-frailty-risk-older-adults-2026a1000lec
Statins and Survival Free of Incident Frailty  https://doi.org/10.1093/eurheartj/ehag451
III LA Posterior Wall Isolation Fails Again
CORNERSTONE Trial https://doi.org/10.1093/eurheartj/ehag486
CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186
IV Does the Display of Test Results Improve Clinical Decisions?
Interval Likelihood Ratios for Clinical Decsion-Making https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500249
Making Sense of Health Statistics https://journals.sagepub.com/doi/full/10.1111/j.1539-6053.2008.00033.x
V AI and the ECG and Saving Doctors
Case Report — AI-Enhanced Diagnostics https://www.nature.com/articles/s41591-026-04454-y
The New York Times article https://www.nytimes.com/2026/06/22/health/artificial-intelligence-heart-damage.html
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Listener feedback, more long-term data on the TAVR/SAVR question, population prevalence of valvular heart disease in the US, and a CMS proposal to expand TAVR coverage are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
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ICD Trends and Outcomes: 15-Year Analysis https://doi.org/10.1093/europace/euag110
MADIT-RIT https://www.nejm.org/doi/full/10.1056/NEJMoa1211107
II More Long Term Data on TAVR vs SAVR
PARTNER 2 Trial https://www.jacc.org/doi/10.1016/j.jacc.2026.03.169
10-Year Outcomes of SAPIEN 3 TAVR or SAVR in Intermediate-Risk Patients https://doi.org/10.1016/j.jacc.2026.03.170
TAVR at a Decade: Editorial https://doi.org/10.1016/j.jacc.2026.04.042
EVOLUT Trial https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5063
Updated 5-year Outcomes of TAVR vs SAVR in AS https://heart.bmj.com/content/early/2026/02/11/heartjnl-2025-327092
NOTION Trial https://doi.org/10.1093/eurheartj/ehae043
PARTNER 3 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2509766
NOTION 2 Trial https://academic.oup.com/eurheartj/article/45/37/3804/7673297
TAVR vs SAVR Editorial : https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehag407/8708044
III The PREVUE-VALVE Study
PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137
IV CMS has Proposed New Coverage for TAVR
CMS Proposal Document https://www.cms.gov/medicare-coverage-database/view/ncacal-decision-memo.aspx?proposed=Y&ncaId=321
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Listener feedback, transcatheter tricuspid valve replacement, a new metabolic disease called CKM, the ARISE-FLUIDS Trial, the BIHCA trial, and temporal trends in ICD therapies are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
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LOSE-AF Trial https://jamanetwork.com/journals/jama/fullarticle/2849335
ARREST-AF Trial https://jamanetwork.com/journals/jamacardiology/fullarticle/2840225
POP-AF Trial https://doi.org/10.1093/eurheartj/ehaf689
PRAGUE-25 Trial https://www.jacc.org/doi/10.1016/j.jacc.2025.04.042
II Transcatheter Tricuspid Valve Replacement
TRISCEND Cost Study https://doi.org/10.1016/j.shj.2026.101049
TRISCEND II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2401918
III More Disease Creation – the CKM Syndrome
ACC/AHA Release First-Ever Guideline for CKM Syndrome https://www.medscape.com/viewarticle/acc-aha-release-first-ever-guideline-ckm-syndrome-2026a1000jbs
CKM Guideline in Circulation https://www.ahajournals.org/doi/10.1161/CIR.0000000000001447
IV Two Trials That Teach Important EBM Lessons
ARISE-FLUIDS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2516225
Dr Josh Farkas Post on X https://x.com/PulmCrit/status/2065064796270022845?s=20
 
V  Bicarbonate for Inpatient Cardiac Arrest –The BIHCA trial
BIHCA Trial https://jamanetwork.com/journals/jama/fullarticle/2850405
VI The Decline of VT in Heart Failure
Trends and Outcomes in ICD Recipients: 15-Year Analysis https://doi.org/10.1093/europace/euag110
Declining Risk of Sudden Death in HF https://www.nejm.org/doi/full/10.1056/NEJMoa1609758
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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Chemical cardioversion in the ED, HF monitoring, weight loss in AF, and surgical LAA excision are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Chemical Cardioversion of AF in the ED: The FLECA-ED Trial
FLECA-ED Rationale paper https://pmc.ncbi.nlm.nih.gov/articles/PMC10299428/
FLECA-ED ESC Slides https://esc365.escardio.org/presentation/321209
Review on Flecainide Use Despite CAST https://doi.org/10.1016/j.hrthm.2025.08.034
RACE 7 ACWAS Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1900353
II Heart Failure Monitoring – The ALLEVIATE-HF Trial
ALLEVIATE-HF Trial https://doi.org/10.1016/j.jacc.2026.03.075
CHAMPION Trial https://doi.org/10.1016/S0140-6736(11)60101-3
GUIDE HF Trial https://doi.org/10.1016/S0140-6736(21)01754-2
ALLEVIATE-HF Editorial: Alerts Are Not Treatment https://doi.org/10.1016/j.jacc.2026.04.014
Steve Stiles Medscape report on CHAMPION https://www.medscape.com/viewarticle/755189
III A Negative Weight Loss Study in AF
LOSE-AF Trial https://jamanetwork.com/journals/jama/fullarticle/2849335
IV Surgical LAA Excision
OPINION Trial https://doi.org/10.1093/eurheartj/ehaf674
LAAOS 3 trial https://www.nejm.org/doi/full/10.1056/NEJMoa2101897
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
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